Hemodynamics in arterial hypertension concurrent with subclinical by pothyroidism
https://doi.org/10.14341/probl200854113-16
Abstract
Myocardial structural changes, right and left ventricular diastolic dysfunction, and central and regional hemodynamic parameters were studied in 91 female patients with grades 1 and 2 arterial hypertension who had long received antihypertensive therapy. According to thyroid function, the patients were divided into 2 groups: 1) 51 patients with subclinical hypothyroidism (SH); 2) 40 women with euthyroidism. SН negatively affected the processes of cardiovascular remodeling: SH patients had a more pronounced ventricular septal hypertrophy, increased end-systolic and diastolic dimensions, and higher left ventricular mass. Thyroid-stimulating hormone level correlated with IVRT and other parameters of right and left ventricular diastolic function. Actually, the patients with SH are predisposed to the development of type 1 diastolic dysfunction. Vascular resistance was increased in both groups, but microcirculatory disorders were more evident in SH. Replacement therapy with levothyroxine promoted the improvement of some Intracardiac, central, and regional hemodynamic parameters.
About the Authors
Ye. M. DuryginaNizhny Novgorod State Medical Academy
Russian Federation
L. G. Strongin
Nizhny Novgorod State Medical Academy
Russian Federation
T. A. Nekrasova
Nizhny Novgorod State Medical Academy
Russian Federation
References
1. Антонов А. А. // Сердце. - 2006. - Т. 5, № 4. - С. 210- 215.
2. Вебер В. Р., Рубанова М. П., Жмайлова С. В., Копина М. II. // Сердеч. недостат. - 2005. - Т. 6, Ns 3. - С. 107-109.
3. Дедов И. И., Мельниченко Г. А., Свириденко Н. Ю. и др. // Вести. РАМН. - 2006. - № 2. - С. 15-22.
4. Крупаткин А. И., Сидоров В. В. Лазерная допплеровская флоуметрия и микроциркуляция крови. - М., 2005. - С. 9-28.
5. Левченко II. А., Фадеев В. В. // Пробл. эндокринол. - 2002. - Т. 48, № 2. - С. 13-22.
6. Маколкин В. И., Осадчий К. К., Гладышева Е. А. // Кардиология. - 2005. - Т. 45, № 2. - С. 24-25.
7. Микроциркуляция в кардиологии. - М., 2004.
8. Новицкая А. Б., Стронгин Л. Г., Некрасова Т. А., Конторщикова К. Н. // Клин. тиреоидол. - 2004. - Т. 2, № 4. - С. 27-31.
9. Angejla В. С, Grossman W. // Circulation. - 2003. - Vol. 107. - P. 659-663.
10. Asmar R, Rudnichl A., Blacher J. et al. // Am. J. Нypertens. - 2001.-Vol. 14.-P. 91-97.
11. Biondi В., Palmieri E. A., Lombardi G. et al. // Thyroid. - 2002. - Vol. 12. - P. 505-510.
12. Faber J., Petersen L., Wiinberg N. et al. // Thyroid. - 2002. - Vol. 12. - P. 319-324.
13. Franklin S. S. // J. Hypertens. - 2001. - Vol. 19. - P. 3-8.
14. Monzani F., Di Bello V., Caraccio N. et al. // J. Clin. Endocrinol. Metab. - 2001. - Vol. 86. - P. 1110-1115.
15. Taddel S., Caraccio N.. Virdis A. et al. // J. Clin. Endocrinol. Metab. - 2003. - Vol. 88. - P. 3731-3737.
16. Vitale G., Galderisl M., Lupoll G. A. et al. // J. Clin. Endocrinol. Metab. - 2002. - Vol. 87. - P. 4350-4355.
Review
For citations:
Durygina Ye.M., Strongin L.G., Nekrasova T.A. Hemodynamics in arterial hypertension concurrent with subclinical by pothyroidism. Problems of Endocrinology. 2008;54(1):13-16. (In Russ.) https://doi.org/10.14341/probl200854113-16
Views:
897
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0).
Email this article 
.jpg){kind=logo}
