Choice of a treatment for Graves disease in children
https://doi.org/10.14341/probl200854129-36
Abstract
Today there are по uniform indications for either treatment for Craves 'disease and the predictors of remission have not been identified. The influence of a combination factors on the outcomes of antithyroid therapy (ATT) was analyzed in 67 children aged 1.5 to 17.6 years by the manifestation of the disease. The group of children having a remission of less than 1 year after therapy discontinuation (n - 31) and that of those who had a recurrence (n = 36), including 17 children with a recurrence after therapy discontinuation and 19 with uncontrolled recurrent thyrotoxicosis during at least 1-year therapy, were compared. Thyrostatic therapy was ascertained to be most effective in prepubertal children as well as in those who has small goiter dimensions, as evidenced by ultrasonography. Due to the high risk of recurrent thyrotoxicosis during or after thyrostatic therapy, planning of radical treatment is more warrantable in pubertal children who had a great goiter (volume > 25 ml) and a high level of AbTPO and in young men. Negative TSH receptor antibody changes following 6 months of ATT are indicative of the high risk of a recurrence, which requires a possible revision of further therapeutic tactics in these patients.
About the Authors
A. V. KiyaevRegional Children's Clinical Hospital No. 1
Russian Federation
M. N. Sumin
Institute of immunology and physiology, Ural Branch, RAS
Russian Federation
L. I. Savelyev
Ural State Medical Academy
Russian Federation
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Review
For citations:
Kiyaev A.V., Sumin M.N., Savelyev L.I. Choice of a treatment for Graves disease in children. Problems of Endocrinology. 2008;54(1):29-36. (In Russ.) https://doi.org/10.14341/probl200854129-36
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