Preview

Problems of Endocrinology

Advanced search

The blood concentrations of testosterone, dehydroepiandrosterone sulfate and free androgen index in women with hirsutism

https://doi.org/10.14341/probl200854242-46

Abstract

Hyperandrogenism is a commonest endocrine disorder in women of reproductive age and a cause of many metabolic diseases. The purpose of this study was to measure the blood levels of androgens in women with hirsutism (Ferriman-Gallwey scale > 8 scores) and to reveal the most informative marker of hyperandrogenism in hirsutism. A hundred forty-nine women aged 18-35 years who complained about hirsutism were examined. The women with hirsitism (Ferriman-Gallwey scale > 8 scores) were observed to have statistically significantly elevated serum levels of total testosterone, dehydroepiandrosterone sulfate, and sex hormone-binding globulin and the high free androgen index (p < 0.001). The increased free androgen index (54.8%) was more frequently detected in hirsutism. This study showed that hirsutism was doubtlessly associated with the elevated serum content of androgens; however, even 34.4% of the females had normal blood leveb of androgens.

About the Authors

D. Kozloviene

Kaunas University of Medicine


Lithuania


G. Kazanavicius

Kaunas University of Medicine


Lithuania


V. Kruminis

Kaunas University of Medicine


Lithuania


References

1. Apridonidze Т., Essah P., Iuorno M. J. et al. // J. Clin. Endocrinol. Metab. - 2005. - Vol. 90, N 4. - P. 929-935.

2. Asuncion M., Calvo R. M., San Millan J. L. et al. // J. Clin. Endocrinol. Metab. - 2000. - Vol. 85. - P. 2434-2438.

3. Azziz R-, Ehrmann D., Legro R. S. et al. // J. Clin. Endocrinol. Metab. - 2001. - Vol. 86. - P. 1626-1632.

4. Azziz R-, Sanchez L. A., Knochenhauer £. S. et al. // J. Clin. Endocrinol. Metab. - 2004. - Vol. 89, N 2. - P. 453-462.

5. Bahceci M., Bilge M., Tuzcu A. et al. // J. Endocrinol. Invest. - 2004. - Vol. 27, N 4. - P. 353-356.

6. Christian R.С, Dumesic D. A., Behrenbeck T. et al. // J. Clin. Endocrinol. Metab. - 2003. - Vol. 88. - P. 2562-2568.

7. Cibula D., HillM., Starka L. // Eur. J. Endocrinol. - 2000. - Vol. 143. - P. 405-40S.

8. Ferriman D., Gallwey J. D. // J. Clin. Endocrinol. Metab. - 1961. - Vol. 21. - P. 1440-1447.

9. Galadari I., Al-Mazroei M., Alkaabi J. // Int. J. Dermatol. - 2004. - Vol. 43, N 4. - P. 2765-2767.

10. Cullu S., Emral R., Asik M. et al. // J. Endocrinol. Invest. - 2003. - Vol. 26, N 12. - P. 1193-1202.

11. Huppert J., Chiodi M., Hillard P.J. // J. Pediatr. Adolesc. Gynecol. - 2004. - Vol. 17, N 2. - P. 103-108.

12. Косак М. // Gynecol. Endocrinol. - 2004. - Vol. 18, N 4. -P. 179-185.

13. Laven J. S., Imani В., Eijkemans M. J., Fauser В. С // Obstet. Gynecol. Surv. - 2002. - Vol. 57. - P. 755-767.

14. Legro R.S. // Endocr. Rev. - 2003. - Vol. 24, N 3. -P. 302-312.

15. Lobo R. A., Carmina E. // Ann. Intern. Med. - 2000. - Vol. 132. - P. 989-993.

16. Obiezu C. V., Scorilas A., Magklara A. et al. // J. Clin. Endocrinol. Metab. - 2001. - Vol. 86, N 4. - P. 1558-1561.

17. Orio F., Palomba S., Cascella T. et al. // J. Clin. Endocrinol. Metab. - 2004. - Vol. 89, N 9. - P. 4588-4593.

18. Orio F., Palomba S., Spinelli L. et al. // J. Clin. Endocrinol. Metab. - 2004. - Vol. 89, N 8. - P. 3696-3701.

19. Plouffe L. // Obstet. Gynecol. Clin. - 2000. - Vol. 27, N 1. - P. 79-99.

20. Richard S., Legro M. D. // Semin. Reprod. Med. - 2003. - Vol. 21, N3.-P. 267-275.

21. Rossi R., Tauchmanova L., Luciano A. et al. // J. Clin. Endocrinol. Metab. - 2001. - Vol. 24, N 7. - P. 491-498.

22. Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group // Hum. Reprod. - 2004. - Vol. 19, N 1. -P. 41-47,

23. Rowe P. J., Comhaire F. H., Hargreave Т. В., Mellows H. J. WHO Manual for the Standardized Investigation and Diagnosis of the Infertile Couple. - 1997.

24. Souter I., Sanchez L. A., Perez M. et al. // Am. J. Obstet. Gynecol. - 2004. - Vol. 196, N 6. - P. 1914-1920.

25. Talbott E. O., Zborowski J. V., Roger J. A et al. // J. Clin. Endocrinol. Metab. - 2004. - Vol. 89, N 11. - P. 5454-5461.

26. Taponen S., Martikainen H., Jarvelin M. R. // J. Clin. Endocrinol. Metab. - 2004. - Vol. 89, N 5. - P. 2114-2118.

27. Wu F. С.W., Eckardstein A. // Endocr. Rev. - 2003. -Vol. 24.-P. 183-217.


Review

For citations:


Kozloviene D., Kazanavicius G., Kruminis V. The blood concentrations of testosterone, dehydroepiandrosterone sulfate and free androgen index in women with hirsutism. Problems of Endocrinology. 2008;54(2):42-46. (In Russ.) https://doi.org/10.14341/probl200854242-46

Views: 3842


ISSN 0375-9660 (Print)
ISSN 2308-1430 (Online)