The reference values of thyroid hormone and the prevalence of subclinical thyroid dysfunctions in adolescents in a mild iodine deficiency area
https://doi.org/10.14341/probl200854414-17
Abstract
The present study was undertaken to determine the reference values of thyroid-stimulating hormone (TSU) in a representative sample of healthy adolescents and to establish the prevalence of subclinical thyroid dysfunction in a mild Iodine-deficiency area (median Ioduria 53 mg/l). An integrated study, involving thyroid ultrasonography, determination of TSH and thyroid peroxidase Ab, was conducted in 1179 children (637 girls and 542 boys) aged 13-16 years in 23 localities of the Sverdlovsk Region. By taking into account the criteria recommended for the determination of the reference ranges of thyroid hormones, the authors formed a sample of 561 adolescents (271 boys and 290 females). The upper TSH range was 5.2 and 4.7 mIU/l for boys and girls, respectively. The established reference values of TSH show it inexpedient to reduce its upper range under the existing conditions of inadequate iodine intake, the prevalence of subclinical hypothyroidism in adolescents prevails over the incidence of subclinical thyrotoxicosis.
About the Authors
A. V. Kiyaev
Regional Children's Clinical Hospital № 1
Russian Federation
Russian Federation
L. I. Savelyev
Ural State Medical Academy of the Ministry of Health and Social Development of the Russian Federation
Russian Federation
Russian Federation
L. Yu. Gerasimova
Regional Children's Clinical Hospital № 1
Russian Federation
Russian Federation
N. P. Koroleva
Regional Children's Clinical Hospital № 1
Russian Federation
Russian Federation
S. N. Boyarsky
Regional Children's Clinical Hospital № 1
Russian Federation
Russian Federation
S. V. Tsirenko
Ural State Medical Academy of the Ministry of Health and Social Development of the Russian Federation
Russian Federation
Russian Federation
References
1. Кияев А. В., Савельев Л. И., Герасимова Л. Ю. и др. // Клин. и экспер. тиреоидол. - 2007. - Т. 3, № 2. - С. 33-38.
2. Aghini-Lombardi F., Antonangeli L., Martino E. et al. // J. Clin. Endocrinol. Mctab. - 1999. - Vol. 84, N 2. - P. 561-566.
3. Baloch Z, Carayon P., Conte-Devolx B. et al. // Thyroid. - 2003.-Vol. 13.-P. 3-126.
4. Becker K. L., ed. Principles and Practice of Endocrinology and Metabolism / Ed. K. L. Becker. 2-nd Ed. - Philadelphia, 1995. - P. 1996-1998.
5. Canaris G. J., Manowitz N. R., Mayor G., Ridgway E. C. // Arch. Intern. Med. - 2000. - Vol. 160. - P. 526-534.
6. Chan M. K., Seiden-Long I., Quinn F. et al. // 17-th IFCC-FESCC European Congress of Clinical Chemistry and Laboratory Medicine. - Amsterdam, 2007. - С 435.
7. Hak A. E., Pols H. A. P., Visser T. J. et al. // An. Intern. Med. -2000. - Vol. 132. - P. 270-278.
8. Hollwell J. G., Staehling N. W., Hannon W. H. et al. // J. Clin. Endocrinol. Metab. - 2002. - Vol. 87, N 2. - P. 489-499.
9. Kabelitz M., Liesenkotter K. P., Stach B. // Eur. J. Endocrinol. -2003. - Vol. 148. - P. 301-307.
10. Kovatcheva R., Borissova A.-M., Shlnkov A. et al. // Horm. Res.: Abstracts 32-nd Annual Meeting of the European Thyroid Association. - 2007. - Vol. 68, N 1. - P. 58.
11. Kratzsch J., Fiedler G. M., Leichtle A. et al. // Clin. Chem. - 2005.- Vol. 51, N 8. - P. 1480-1486.
12. Ladenson P. W, Singer P. A., Ain К. В. et al. // Arch. Intern. Med. - 2000. - Vol. 160. - P. 1573-1575.
13. Solberg H. E. // J. Clin. Chem. Clin. Biochem. - 1987. -Vol. 25. - P. 645-656.
14. Soldin S. J., Morales A., Albalos F. et al. // Clin. Biochem. - 1995. - Vol. 28. - P. 603-606.
15. Surks M. I., Chopra I. J., Mariash С. N. et al. // J. A. M. A. -1990. - Vol. 263. - P. 1529-1532.
16. Wu Т., Flowers J. W., Tudiver F. et al. // BMC Pediatr. - 2006.- Vol. 19. - P. 6-12.
17. Zimmermann M. В., Molinari L., Spehl M. et al. // IDD Newsletter. - 2001. - Vol. 17, N 1. - P. 12.
18. Zurakowski D., Di Canzio J., Majzoub J. A. // Clin. Chem. - 1999. - Vol. 45, N 7. - P. 1087-1091.
Review
For citations:
Kiyaev A.V., Savelyev L.I., Gerasimova L.Yu., Koroleva N.P., Boyarsky S.N., Tsirenko S.V. The reference values of thyroid hormone and the prevalence of subclinical thyroid dysfunctions in adolescents in a mild iodine deficiency area. Problems of Endocrinology. 2008;54(4):14-17. (In Russ.) https://doi.org/10.14341/probl200854414-17
Views:
11457
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0).
Email this article 
.jpg){kind=logo}
