Dysmenorrhea concurrent with insulin resistance in adolescent girls

Abstract

Polycystic ovary syndrome (POS) is one of the most common causes of infertility in women of reproductive age. There have been recent reports on a significant role of Insulin resistance in the pathogenesis of this abnormality. The present study applying a com-prehensive diagnostic approach has revealed the specific features of clinical, hormonal, and metabolic disorders in adolescent girls in the presence of menstrual dysfunction concurrent with insulin resistance, which could identify different pathogenetic mechanisms of the above disorders. It was found that in female obese adolescents, menstrual dysfunction might be caused by compensatory hy-perinsulinemia and insulin resistance in the presence of visceral obesity. The manifestations of mixed hyperandrogenism caused by impaired steroidogenesis associated with increased p450c 17a activity come to the forefront in the group of patients with normal weight and insulin resistance.