Vasoconstrictive peptide en-dolhelin-1 in children and adolescents with type 1 diabetes mellitus
https://doi.org/10.14341/probl200854512-16
Abstract
The plasma vasoconstrictive peptide endothel'in-1 that is one of the markers of endothelial dysfunction was studied in children and adolescents with type 1 diabetes. The findings suggest vascular endothelial dysfunction In patients with a 5-year history of the disease; in patients with the same duration of the disease, the level of endothelin-1 is increased in prolonged carbohydrate metabolic decom-pensation, dyslipidemia, and Increased urinary albumin excretion (particularly in macroalbuminuria greater than 300 mg/l). It may be presumed that the test peptide endothelin assumes a diagnostic value in the prolonged (more than 5 years) and poor course of type 1 diabetes.
About the Authors
V. N. Panfilova
Krasnoyarsk State Medical Academy of the Federal Agency for Health and Social Development
Russian Federation
Russian Federation
T. Ye. Taranushenko
Krasnoyarsk State Medical Academy of the Federal Agency for Health and Social Development
Russian Federation
Russian Federation
N. K. Golubenko
Krasnoyarsk Regional Children's Hospital
Russian Federation
Russian Federation
S. M. Lobanova
Krasnoyarsk Regional Children's Hospital
Russian Federation
Russian Federation
O. A. Terentyeva
Krasnoyarsk Regional Children's Hospital
Russian Federation
Russian Federation
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Review
For citations:
Panfilova V.N., Taranushenko T.Ye., Golubenko N.K., Lobanova S.M., Terentyeva O.A. Vasoconstrictive peptide en-dolhelin-1 in children and adolescents with type 1 diabetes mellitus. Problems of Endocrinology. 2008;54(5):12-16. (In Russ.) https://doi.org/10.14341/probl200854512-16
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