Levels of insulin, C-peptide, and hydrocortisone in the course of glucose tolerance test in indigenous population of the Extreme North and in newcomers
https://doi.org/10.14341/probl19974327-10
Abstract
The reaction of beta-cells and hydrocortisone levels after standard glucose test were compared in the indigenous population of the Extreme North and newcomers in two Northern regions — the Arctic and continental. Residents of Central Siberia were controls. In Northern residents the concentrations of insulin and C-peptide and their increase after glucose loading were reliably lower than in the residents of Siberia, being the lowest in the indigenous population of and newcomers to the Arctic region. Basal level of hydrocortisone in the blood of residents of the Extreme North was higher than in residents of Central Siberia, but glucose intake led to a decrease of the hormone content and leveled the differences in its concentrations in all examinees. Glucose tolerance in the presence of low insulinemia was normal in residents of the Extreme North.
About the Authors
S. A. DogadinInstitute of Medical Problems of the North SB RAMS; Endocrinology Center of Regional Clinical Hospital No. I
Russian Federation
K. G. Nozdrachev
Institute of Medical Problems of the North SB RAMS; Endocrinology Center of Regional Clinical Hospital No. I
Russian Federation
Ye. V. Krizhanovskaya
Institute of Medical Problems of the North SB RAMS; Endocrinology Center of Regional Clinical Hospital No. I
Russian Federation
V. T. Manchuk
Institute of Medical Problems of the North SB RAMS; Endocrinology Center of Regional Clinical Hospital No. I
Russian Federation
References
1. Авцын А. П., Жаворонков А. А., Марачев А. Г., Милованов А. П. Патология человека на Севере. — М., 1985.
2. Казначеев В. П. // Экология человека. Основные проблемы. - М., 1988. - С. 9-32.
3. Никитин Ю. П. // Вестн. АМН СССР. - 1989. - № 5. - Q 35—39.
4. Орехов К. В. // Там же. — 1979. — № 6. — С. 73—81.
5. Панин Л. Е. Энергетические аспекты адаптации. — Л., 1978.
6. Седов К. Р., Догадин С. А. // Бюл. Сиб. отд. АМН СССР. - 1990. - № 1. - С. 17-22.
7. Цуканов В. В., Тонких Ю. Л. // Новые направления в гепатологии. Фальк симпозиум № 29. — СПб., 1996. — С. 413.
8. Шварева Н. В. // Физиология человека. — 1990. — Т. 16, № 2. - С. 90-97.
9. Шварева Н. В., Ткачев А. В. // Там же. — 1983. — Т. 9, № 4. - С. 537-544.
10. Granberg Р.-О. // Art. Med. Res. — 1995. — Vol. 54, N 3. — P. 91-103.
11. Levine M. E, Milliron A. N., Duffy L. K. // Ibid. - 1994. - Vol. 53, N 1. - P. 25-34.
12. Miller B. J. C., Collaguiri S. // Diabetologia. — 1992. — Vol. 37, N 2. - P. 1280-1286.
13. Moffat M. E. K., O'Neil J., Young T. K. // Art. Med. Res. - 1994. - Vol. 53, Suppl. 2. - P. 298-300.
14. Newsholme E. A. // J. molec. Med. - 1977. - Vol. 2, N 4. - P. 405-412.
15. Rossetti L., Rothman D. L., DeFronzo R. A., Schulman G. I. // Amer. Physiol. - 1989. - Vol. 257. - P. E212-E219.
16. Schaefer O. // Trans. Roy. Soc. Can.— 1981. — Vol. 20, Ser. IV.- P. 417-427.
17. Tkachev A. V., Ramenskaya E. V., Bojko E. R. // Art. Med. Res. - 1994. - Vol. 50, Suppl. 6. - P. 152-155.
18. Young T. K., Schraer C. D., Shubnikoff E. V. et al. // lnt. J. Epidemiol. - 1992. - Vol. 21, N 4. - P. 730-736.
Review
For citations:
Dogadin S.A., Nozdrachev K.G., Krizhanovskaya Ye.V., Manchuk V.T. Levels of insulin, C-peptide, and hydrocortisone in the course of glucose tolerance test in indigenous population of the Extreme North and in newcomers. Problems of Endocrinology. 1997;43(2):7-10. (In Russ.) https://doi.org/10.14341/probl19974327-10
Views:
1258
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0).
Email this article 
.jpg){kind=logo}
