Hepoxylins - activators of ATP-dependent K + channels B cells of the pancreas are normal and in pathology
https://doi.org/10.14341/probl199743528-31
Abstract
ATP-dependent channels of pancreatic ft-cells functionally attenuated by streptosotocin and their reaction to hepoxylin HxB3 are analyzed. Highly specific response of the above ionic channels to glucose and HxB3 hepoxylin was observed. Analysis of the time course of electrophysiological processes in the channels showed appreciable changes in the time of their closure, which resulted in a slower secretion of insulin starting from the moment of glucose and hepoxylin exposure and till the moment of exocytosis of insulin quantum. Under experimental conditions hepoxylin was a more potent inductor of secretion than glucose.
About the Authors
V. N. BabichevEndocrinology Research Center
Russian Federation
N. S. Ignatiev
Endocrinology Research Center
Russian Federation
M. I. Balabolkin
Endocrinology Research Center
Russian Federation
K. K. Pivnitsky
Endocrinology Research Center
Russian Federation
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Review
For citations:
Babichev V.N., Ignatiev N.S., Balabolkin M.I., Pivnitsky K.K. Hepoxylins - activators of ATP-dependent K + channels B cells of the pancreas are normal and in pathology. Problems of Endocrinology. 1997;43(5):28-31. (In Russ.) https://doi.org/10.14341/probl199743528-31
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