The effect of glurenorm on blood pressure in patients with non-insulin-dependent diabetes mellitus with hypertension

Abstract

Effects of long glurenorm therapy on daily arterial pressure (AP), central hemodynamics, and diastolic function of the left ventricle were assessed in patients with non-insulin-dependent diabetes with stages I and II essential hypertension. The patients were divided in 2 groups: group I (n=24) treated with manilil (5-20 mg/day) and nifedipin (20-50 mg/day) and group II (n=24) treated with glurenorm (60-150 mg/day). Control groups consisted of diabetics without arterial hypertension: group III, glurenorm, and group IV, manilil. AP decreased in 88% of patients in groups I and II during the second week of treatment, the maximal decrease was observed by the and of week 12. Decrease of AP in groups I and II was paralleled by a decrease of the total peripheral resistance, improvement of leftventricular diastolic function, and no effect of myocardial contractility. One probable mechanism of the hypotensive and vasodilating effect of glurenorm is decrease of basal insulin level, whose values were higher in groups I and II in comparison with the control and correlated with daily AP values.