Simultaneous measurement of corticosterone and 11-dehydrocorticosterone in the adrenals and plasma in acute stress
https://doi.org/10.14341/probl11315
Abstract
Adrenal and plasma levels of corticosterone and 11-dehydrocorticosterone were measured in intact and stressed (laparotomy) rats by microcolumn high performance liquid chromatography. In contrast to humans, in rats plasma level of basic glucocorticoid is essentially higher than the level of its reversible metabolite. Acute stress (laparotomy) led to an increase in the adrenal concentration of 11-dehydrocorticosterone and plasma concentration of corticosterone, which was regarded as creation of a reserve corticosterone pool.
About the Authors
О. P. CherkasovaInstitute of Laser Physics, Siberian branch of the Russian Academy of Sciences
Russian Federation
V. I. Fedorov
Institute of Laser Physics, Siberian branch of the Russian Academy of Sciences
Russian Federation
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Review
For citations:
Cherkasova О.P., Fedorov V.I. Simultaneous measurement of corticosterone and 11-dehydrocorticosterone in the adrenals and plasma in acute stress. Problems of Endocrinology. 2001;47(1):37-39. (In Russ.) https://doi.org/10.14341/probl11315
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