Chronic gastroduodenal ulcers in patients with diabetes mellitus
https://doi.org/10.14341/probl11321
Abstract
The clinical picture, course, and treatment of gastroduodenal ulcers (GDU) in diabetics were studied. A total of 395 diabetics were examined; GDU were detected in 36. The incidence of gastric and duodenal ulcers was similar in patients with insulin-dependent diabetes mellitus, while in patients with non-insulin-de- pendent diabetes gastric ulcers predominated. The clinical picture of the disease, gastric acid production, Helicobacter pylori infection, and blood gastrin levels were studied in all patients with ulcers. The efficiency of GDU treatment with quamatel, ranitidine, and antacids was evaluated. The clinical course of GDU in diabetics was asymptomatic. The highest incidence of H. pylori, infection was observed in patients with type 1 diabetes with concomitant peptic ulcers. Serum gastrin levels were more frequently increased in patients with type 1 diabetes and duodenal ulcers and normal in patients with type 2 diabetes. Quamatel therapy was highly effective in diabetics with GDU. Ulcers healed in 85% patients and blood gastrin level significantly decreased after 3- week therapy. GDU in diabetics are characterized by specific location, clinical course, laboratory and instrumental features, which allows a differentiated approach to therapy of these patients.
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Review
For citations:
Fedorchenko Yu.L. Chronic gastroduodenal ulcers in patients with diabetes mellitus. Problems of Endocrinology. 2003;49(1):7-12. (In Russ.) https://doi.org/10.14341/probl11321
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