Basal and LH-RH-stimulated gonadotropin secretion in oophorectomized female rats with streptozotocin-induced diabetes
https://doi.org/10.14341/probl11331
Abstract
In vitro insulin effect on basal and LH-RH- stimulated gonadotropin secretion in oophorectomized female rats with streptozotocin diabetes administered estradiol as replacing hormone therapy was studied. The results were compared to those obtained after a similar incubation of adenohypophyses of oophorectomized rats and of oophorectomized rats administered estradiol. Estradiol was found to change the type of LH-RH-stimulated gonadotropin secretion in oophorectomized animals. Basal, but not LH-RH-stimulated gonadotropin secretion, was increased in rats with experimental diabetes as against other groups. Insulin inhibited basal and increased LH-RH-stimulated gonadotropin secretion in oophorectomized rat’s with streptozotocin diabetes administered estradiol. A conclusion is made about impaired sensitivity of hypophyseal gonadotrophs to LH-RH in streptozotocin diabetes and about a possible contribution of insulin to regulation of body reproductive system at the level of hypophysis.
About the Authors
V N Babichev
Endocrinology Research Centre
Russian Federation
Russian Federation
Ye L Adamskaya
Endocrinology Research Centre
Russian Federation
Russian Federation
T A Peryshkova
Endocrinology Research Centre
Russian Federation
Russian Federation
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Review
For citations:
Babichev V.N., Adamskaya Ye.L., Peryshkova T.A. Basal and LH-RH-stimulated gonadotropin secretion in oophorectomized female rats with streptozotocin-induced diabetes. Problems of Endocrinology. 1994;40(1):43-46. (In Russ.) https://doi.org/10.14341/probl11331
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