T-lymphocyte precursors in diabetics
https://doi.org/10.14341/probl11356
Abstract
Patients with types I, II, and pancreatogenic diabetes mellitus were examined for the counts of T precursor cells using autorosette formation test in the presence of t-activin, an activator of T lymphocyte differentiation. The counts of T lymphocyte precursors in patients with type II and pancreatogenic diabetes were virtually the same as in normal subjects. Disorders of cellular immunity in type I diabetes mellitus were found to be associated with depletion of pre-T-lymphocytes. These changes were the most manifest in the decompensation phase (ketoacidosis state). The results may be useful in development of immunomodulating therapy for type I diabetes and in prediction of the disease development in subjects predisposed to it.
About the Authors
Ye. A. ZhukNovosibirsk medical Institute
Russian Federation
V. A. Galenok
Novosibirsk medical Institute
Russian Federation
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Review
For citations:
Zhuk Ye.A., Galenok V.A. T-lymphocyte precursors in diabetics. Problems of Endocrinology. 1995;41(2):4-6. (In Russ.) https://doi.org/10.14341/probl11356
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