The value of the simultaneous determination of content glycated proteins and antibodies to islet cells in children and adolescents

An assessment was made of the potentiality of identification of individuals at risk for type 1 diabetes mellitus (DM) among children with transient hyperglycemia by simultaneously determining the levels of antibodies to pancreatic islet cell antigens (ICA) and insulin antigen (IA), as well as glycated proteins of different life span.

The content of antibodies to ICA and IA was measured in 76 children and adolescents aged 3 to 20 years who had a history of transient hyperglycemia and in 18 children of the same age who had DM-characteristic complaints. They also underwent a glucose tolerance test and the levels of glycated hemoglobin (HbAlc), glycated hair keratin (GHK), and glycated fibrinogen (GF) were de­termined.

The children with a history of transient hyperglycemia, those with impaired glucose tolerance, and a group of individuals with fasting glycemic disturbances were found to have higher levels of glycated proteins (GHK and HbAlc) and a significantly more frequency of and higher titers of antibodies to IS and ICA than in the children from the control group and in those without carbohydrate metabolic disturbances.

glycated proteins, glycated hemoglobin, glycated hair keratin, glycated fibrinogen, islet cell antibodies, insulin antibodies

1. Вартанян Н. Л., Соминина А. А., Зарубаев Е. В. и др. // Пробл. эндокринол. — 2000. — № 3. — С. 3-7.

2. Галенок В. А., Ханыкина И. В. // Пробл. эндокринол. — 1992. - № 1. - С. 20-22.

3. Нерсенян С. А. Некоторые гормональные аспекты становления ранних стадий сахарного диабета у лиц с отягощенной наследственностью в зависимости от типа диабета родителей: Автореф. дис. ... канд. мед. наук. — СПб, 1993.

4. Петряйкина Е. Е. // Сахарный диабет. — 2000. — № 3. — С. 43-44.

5. Рахимова Г. Н., Акбаров 3. С., Туракулов Я. X. // Пробл. эндокринол. — 1992. — № 3. — С. 21-23.

6. Bosi Е., Garancini М. Р., Poggiali F. et al. // Diabetologia. —1999- Vol. 42, N 7. - P. 840-844.

7. Boyden S. V. // J. Exp. Med. - 1956. - Vol. 93. - P. 107.

8. Chao T., Tsai S. T, Lee T. S., Hwang B. // Chung Hua Min Kuo Hsiao Erh Ko I Hsueh Hui Tsa Chih. — 1996. — Vol. 37, N 6. - P. 444-447.

9. Colman P. G., McNair P., Margetts H. et al. // Med. J. Aust. - 1998. - Vol. 169, N 2. - P. 81-84.

10. Pastore M. R., Bazzigaluppi E., Bonfanti R. et al. // Diabetes Care. - 1998. - Vol. 21, N 9. - P. 1445-1450.

11. Strebelow M., Sehlosser M., Ziegler B. et al. // Diabetologia. — 1999. - Vol. 42, N 6. - P. 661-671.