Magnetic resonance imaging in the diagnosis of hypothalamopituitary diseases in patients with true premature sexual development
https://doi.org/10.14341/probl11438
Abstract
То evaluate the incidence of different types of organic abnormalities occurring in premature sexual development (PSD) of central genesis and to study a role of magnetic resonance imaging (MRI) in the diagnosis of PSD, MRI was used in 33 patients with a clinically established diagnosis of true (gonadotropin-dependent) PSD of central genesis. Among the examined children with PSD, hypothalamic hamartoma was detected in 27.3%) of the patients; there were no MRI data suggesting hypothalamopituitary abnormalities in 72.7%o. On the MRI images, a hypothalamic hamartoma appeared as a round or oval mass having a well -defined outlines, a homogeneous structure, 3 to 15 mm in size, which is located in the projection of mamillary bodies or retrochiasmally. Patients with PSD were found to have an increased volume of the adenohypophysis mainly due to the vertical size as compared with a group of healthy children of the same age.
About the Authors
A. V. VorontsovEndocrinological Research Center of the Russian Academy of Medical Sciences
Russian Federation
T. V. Semicheva
Endocrinological Research Center of the Russian Academy of Medical Sciences
Russian Federation
V. A. Peterkova
Endocrinological Research Center of the Russian Academy of Medical Sciences
Russian Federation
References
1. Boyko О. В., Curnes J. Т., Oakes W. J. // Am. J. Roentgenol. 1991. - Vol. 156. - P. 1053-1058.
2. De Sanctis V., Corrias A., Rizzo V. // J. Pcdiatr. Endocrinol. Metab. - 2000. - Vol. 13. - Suppl. 1. - P. 687-693.
3. Cisternino M., Arrigo T., Pasquino A. M. // Ibid. - P. 695- 701.
4. Gupta R., Ammini A. C. // Pediatr. Radiol. - 1996. - Vol. 26, N 6. - P. 418-420.
5. Hayakawa M., Konishi Y., Matsuda T. // Radiology. - 1989. Vol. 172. - P. 171-177.
6. Kao S. C., Cook J. S., Hansen J. R. // Pediatr. Radiol. - 1992. - Vol. 22, N 7. - P. 481-484.
7. Kornreich L., Horev G., Blaser S. // Ibid. - 1995. - Vol. 25, N 1. - P. 7-11.
8. Robben S. G., Oostdijk W., Drop S. L. // Br. J. Radiol. - 1995. - Vol. 68. - P. 34-38.
9. Sharafuddin M. J., Luisiri A., Garibaldi L. R. // Am. J. Roentgenol. - 1994. - Vol. 162, N 5. - P. 1167-1173.
Review
For citations:
Vorontsov A.V., Semicheva T.V., Peterkova V.A. Magnetic resonance imaging in the diagnosis of hypothalamopituitary diseases in patients with true premature sexual development. Problems of Endocrinology. 2003;49(1):32-36. (In Russ.) https://doi.org/10.14341/probl11438
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