Chorionic gonadotropin regulation of intracellular potassium levels in human blood immunocompetent cells; a role of phases of a menstrual cycle

Abstract

The effect of chorionic gonadotropin (CG) on intracellular po­tassium ion( [K${}^{+}$]${}_i$) levels in human blood immunocompetent cells was studied by taking into account the phases of a menstrual cy­cle. CG was used in doses of 10, 50, and 100 IU/ml. Plasma photometry was used to measure the level of [K${}^{+}$]${}_i$ in the frac­tionated peripheral monocytes and lymphocytes from males, as well as from females in the late follicular and luteal phases of a menstrual cycle. CG used in a dose of 100 IU/ml was found to lower flCf in the monocytes and lymphocytes of males and in a dose of 50 IU in the lymphocytes of females in the luteal phase of a menstrual cycle. The hormone used in large doses stabilized the level of [K+]${}_i$ in both types of cell of female in the follicular phase. It is concluded that CG can modulate the level of [K+]${}_i$ in human peripheral blood immunocompetent cells, and the direc­tionality of its effects depends on a type of hormone-accepting cells and it is determined by a menstrual phase.