Neurophysiological effects of corticotropin-releasing factor in the undergoing sections of the olfactory area of the rat cerebral cortex
https://doi.org/10.14341/probl11446
Abstract
Application of corticotrophin-releasing factor (CPF) in concentrations of - M on the rat olfactory cortex slices induced activation of the pre- and postsynaptic excitatory components of the focal potentials recorded in the slices. The amplitude and duration of α-amino-3-hydroxy-5-methyl-isoxazole-4-propionic and N-methyl-D-aspartate components of postsynaptic evoking potentials increased upon exposure to CRF, while the amplitude of GABAB-mediated inhibitory postsynaptic potentials was suppressed. At higher concentrations of CRF ( M) epileptiform charges were recorded in the cells. CRF effects were reversible and eliminated after washing. A long (90 min) exposure induced the phenomena similar to long-term posttetanic potentiation. The findings suggest that CRF has pronounced activating properties and ajfects the glutamatergic and GABAergic systems.
About the Authors
A. A. MokrushinPavlov Institute of Physiology of the Russian Academy of Sciences
Russian Federation
V. G. Shalyapina
Pavlov Institute of Physiology of the Russian Academy of Sciences
Russian Federation
References
1. Мокрушин А. А. Пептид-зависимые механизмы нейрональной пластичности в обонятельной коре: Автореф. дис. ... д-ра биол. наук. - СПб., 1997. - С. 3-42.
2. Шаляпина В. Г., Рыбникова Е. А., Ракицкая В. В. // Рос. физиол. журн. - 1998. - Т. 84, № 10. - С. 1146-1151.
3. Aldenhoff J. В., Gruol D. L., Rivier J. et al. // Science. - 1983. Vol. 221, N 4613. - P. 875-877.
4. Aldenhoff J. B. // Psychoendocrinology. - 1986. - Vol. 11, N 2. - P. 231-236.
5. Chaimers D. T., Lovenberg T. W., De Souza E. B. // J. Neuro- sci. - 1995. - Vol. 15. - P. 6340-6350.
6. Curtis A. L., Lechner S. M., Pavcovich L. A. // J. Pharmacol. Exp. Ther. - 1997. - Vol. 281. - P. 163-172.
7. De Souza E. B. // J. Neurosci. - 1987. - Vol. 7. - P. 88- 100.
8. Dunn A. J., Berridge C. W. // Brain Res. Rev. - 1990. - Vol. 15, N 2. - P. 71-100.
9. Eberly L. B., Dudley C. A., Moss R. L. // Peptides. - 1983. - Vol. 4. - P. 837-841.
10. Ehlers C. L., Henriksen S. J., Wang M. ct al. // Brain Res. - 1983. - Vol. 278. - P. 332-336.
11. Koob G. E, Bloom F. E. // Fed. Proc. - 1985. - Vol. 44. - P. 259-263.
12. Koob G. E, Markou A., Weiss F. // Semin. Neurosci. - 1993. Vol. 5. - P. 351-358.
13. Koob G. F., Heinrichs S. C. // Brain Res. - 1999. - Vol. 848, N 1-2. - P. 141-152.
14. Marrosu E, Mereu G., Fratta W. // Ibid. - 1987. - Vol. 408 P. 394-398.
15. Perrin M., Donaldson C., Chen R. et al. // Endocrinology. - 1993. - Vol. 133. - P. 3058-3061.
16. Perrin M., Donaldson C., Chen R. et al. // Proc. Natl. Acad. Sci. USA. - 1995. - Vol. 92. - P. 2969-2973.
17. Swanson L. W., Sawchenko P. E., Rivier J. et al. // Neuroendocrinology. - 1983. - Vol. 36. - P. 165-186.
18. Valentino R. J., Foote S. L., Aston-Lones G. // Brain Res. - 1983. - Vol. 270, N 2. - P. 363-367.
Review
For citations:
Mokrushin A.A., Shalyapina V.G. Neurophysiological effects of corticotropin-releasing factor in the undergoing sections of the olfactory area of the rat cerebral cortex. Problems of Endocrinology. 2003;49(1):51-53. (In Russ.) https://doi.org/10.14341/probl11446
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