Segregation analysis of diffuse toxic goiter

Abstract

The authors discuss segregation analysis of diffuse toxic goiter based on 34 histories selected for the proband. In 11 families one of the parents and the child were ill, in 23 the proband’s parents were healthy. Weinberg’s method of solitary registration was used. No correspondence of the monogenic model of disease inheritance was observed for families with the hypothesized autosomal dominant and autosomal recessive types of inheriting.