Insulin loading and some hormonal metabolic parameters in patients with the hypothalamic syndrome
https://doi.org/10.14341/probl11487
Abstract
Thirty-two men aged 18 to 28 with the hypothalamic syndrome and 64 age-matched healthy men were examined. Insulin test was carried out in 3 steps: before and 30 and 120 min after intravenous infusion of 0.15 U insulin per kg b.w. At all stages of insulin test, spirography parameters reflected the status of hypermetabolism connected with increased energy consumption and with a lesser efficacy of oxygen utilization. Measurements of hormones: ACTH, STH, and hydrocortisone in the blood and of adrenaline, noradrenaline, dopamine, and DOPA in the urine indicated a reduced regulatory function of the hypothalamo-pituitary-adrenal and sympathoadrenal systems in patients with the hypothalamic syndrome. Time course of IRI, glucose, pyruvate, and lactate levels in the blood plasma of patients with the hypothalamic syndrome was indicative of reduced insulin and glucose tolerance and of impaired utilization of glucose as an energy substrate.
About the Authors
Ye. I. SokolovMoscow medical dental Institute named after N. A. Semashko
Russian Federation
A. P. Zayev
Moscow medical dental Institute named after N. A. Semashko
Russian Federation
T. P. Khovanskaya
Moscow medical dental Institute named after N. A. Semashko
Russian Federation
S. A. Zhizhina
Moscow medical dental Institute named after N. A. Semashko
Russian Federation
S. V. Petrin
Moscow medical dental Institute named after N. A. Semashko
A. S. Razin
Moscow medical dental Institute named after N. A. Semashko
Russian Federation
V. K. Filonov
Moscow medical dental Institute named after N. A. Semashko
Russian Federation
References
1. Ахметова Б. С. // Вопросы патологии эндокринной системы. — Алма-Ата, 1984. — С. 88—91.
2. Дильман В. М. Четыре модели медицины. — Л., 1987.
3. Заев А. П., Жижина С. А. // Физиология человека. — № 1. — С. 153—156.
4. Лазарева С. А., Симиренко Л. Л., Бондарь Т. H. и др. // Научно-технический прогресс в кардиологии. — Харьков, 1986. — С. 143—444.
5. Марова Е. И., Арапова С. Д. // Пробл. эндокринол. — 1975. — № 6. — С. 36— 42.
6. Мухитдинова Г. Н. Функциональное состояние сердечнососудистой системы у больных с гипоталамическим синдромом: Автореф. дис. ... канд. мед. наук. — Ташкент, 1982.
7. Пименов Л. Т., Лещинский Л. А., Трусов В. В. // Клин, мед. — 1986. — № 7. — С. 86—91.
8. Скулачев В. П. Биоэнергетика: Мембранные преобразователи энергии. — М., 1989.
9. Теппермен Дж, Теппермен X. Физиология обмена веществ и эндокринной системы. Вводный курс. — М., 1989.
10. Davies А. О, Lefkowit-.P. J. //Ann. Rev. Physiol. — 1984. — Vol. 46. — P. 119.
11. Edwards C. R., Resser G. M. // Clin. Endocr. — 1974. — Vol. 3. — P. 475—505.
12. Fink R. J., Kolterman O. G., Griffin J, Ohesky J. M. // J. clin. Invest. —1983. — Vol. 71, N 6. — P.
13. Golay A., Schutz Y, Meyer H. U. et al. // Diabetes. — 1982. — Vol. 31. — P. 1023—1028.
14. Minaker K. L, Rowe J. W, Young J. B. et al. // Metabolism. — 1982. — Vol. 31, N 12. — P. 1181—1 184.
15. Nosadini R., Del Prato S., Tiengo A. et al. // J. clin. Endocr. — 1983. — Vol. 57, N 7. — P. 529—536.
16. Wajechenberg В. L., Gianella-Neto D., Lerario A. C. et al. // Hormone Res. — 1988. — Vol. 29, N 1. — P. 7—13.
Review
For citations:
Sokolov Ye.I., Zayev A.P., Khovanskaya T.P., Zhizhina S.A., Petrin S.V., Razin A.S., Filonov V.K. Insulin loading and some hormonal metabolic parameters in patients with the hypothalamic syndrome. Problems of Endocrinology. 1995;41(6):16-19. (In Russ.) https://doi.org/10.14341/probl11487
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