Lipid peroxidation in purulent wound tissues in patients with diabetes mellitus

Abstract

The works of recent years have summed up certain results of the study of the processes of free radical lipid oxidation (FRLO) in patients with diabetes mellitus (DM). In these studies, the intensification of the FRLO processes is unequivocally stated. It has been established that chronic insulin deficiency, which acts as a stress factor, activation of lipolysis, and the entry into the vascular bed of a large amount of free fatty acids are a prerequisite for the activation of FRLO. It is known that free radicals have a damaging effect at the level of tissues and cells, participate in the mechanism of destruction of the vascular endothelium, inhibit the synthesis of prostacyclin, a physiological inhibitor of platelet aggregation.

The above suggests a very significant role of the FRLO processes in the pathogenesis of purulent-inflammatory complications of diabetes, important factors in the occurrence of which are neuropathy and regional ischemia, which develops as a result of diabetic angiopathies, and gross structural disorders of the microvasculature.

The mentioned studies mainly concerned the study of the indicators of FRLO and antioxidant protection in the blood in the experiment and in the clinic. The study of these processes in the tissues of a purulent wound in patients with diabetes to date, according to the literature, has not been carried out, which was the basis for this study.