Cytogenetic activity of testosterone propionate and methyltestosterone in a culture of lymphocytes of healthy women and of women suffering from hyperandrogenysm
https://doi.org/10.14341/probl11559
Abstract
To discover the effects of various concentrations of androgenic preparations on lymphocyte cultures from healthy women (group 1) and of women with hyperandrogenism (group 2), a total of 6792 metaphases were examined after peripheral blood lymphocyte culturing after Hangerford. The data indicated a relatively high incidence of aberrant metaphases, total number of ruptures and paired ruptures in the second group, a higher cytogenetic activity of testosterone propionate in both groups, and a higher cytogenetic activity of androgenic hormones in the second group. Bearing in mind a similar, if not higher, activity of endogenic testosterone in a female organism, we must admit a high probability of genetic system involvement in women suffering from hyperandrogenism.
About the Authors
G G DolyanArmenian Research Centre for childen and maternal health protection
Armenia
A A Martirosyan
Armenian Research Centre for childen and maternal health protection
Armenia
References
1. Попенко С. Е., Хомасуридзе А. Г. // Пробл. эндокринол.— 1976,— № 5,— С. 44—45.
2. Родкина Р. А., Зинковский В. В., Фокеева Т. И., Астафьева Е. М. // Акуш. и гин.— 1977.—№ 9.—С. 21—24.
3. Трепаков Е. А., Крымская М. Л., Петухова Л. В. и др. // Медико-генетические исследования в акушерстве и гинекологии,—М„ 1977,—С. 166—170.
4. Breuer Н. // Androgenization in Women Acne Seborrhoea, Androgenetic Alopecia and Hirsutism: Lectures and Discussions of a Symposium.— Berlin, 1980.— P. 21—30.
5. Hangerford D. A. // Stain Technol.— 1965.— Vol 40, N 6.— P. 333—336.
Review
For citations:
Dolyan G.G., Martirosyan A.A. Cytogenetic activity of testosterone propionate and methyltestosterone in a culture of lymphocytes of healthy women and of women suffering from hyperandrogenysm. Problems of Endocrinology. 1994;40(2):42-43. (In Russ.) https://doi.org/10.14341/probl11559
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