The content of tumor necrosis factor A and interleukin-1 in the blood serum of patients with autoimmune thyroid diseases
https://doi.org/10.14341/probl11568
Abstract
Thyroid hormones, antibodies to thyroglobulin, and cytokines tumor necrosis factor a (TNF-a) and interleukin 1 (IL-1) were measured in 14 patients with diffuse toxic goiter (DTG) and 6 patients with Hashimoto ’s autoimmune thyroiditis (AIT). Patients with DTG were examined in the presence of hyperthy- rosis and those with AIT in the presence of euthyrosis. The data indicate a relationship between the levels of TNF-a and thyroid hormones: negative correlation in hyperthyrosis and positive in euthyrosis. In addition, patients with AIT develop a direct correlation between TNF-a and serum titer of antithyroglobulin antibodies. Serum level of IL-1 do not increase. The results of this study confirm the hypothesis about important role of cytokines in pathogenesis of autoimmune diseases of the thyroid, namely, DTG and AIT.
About the Authors
Ya. V. BlagosklonnayaSt. Petersburg State Medical University Acad. I.P. Pavlova
Russian Federation
S. A. Ketlinsky
St. Petersburg State Medical University Acad. I.P. Pavlova
Russian Federation
E. I. Krasilnikova
St. Petersburg State Medical University Acad. I.P. Pavlova
Russian Federation
A. Yu. Kotov
St. Petersburg State Medical University Acad. I.P. Pavlova
Russian Federation
A. Yu. Babenko
St. Petersburg State Medical University Acad. I.P. Pavlova
Russian Federation
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Review
For citations:
Blagosklonnaya Ya.V., Ketlinsky S.A., Krasilnikova E.I., Kotov A.Yu., Babenko A.Yu. The content of tumor necrosis factor A and interleukin-1 in the blood serum of patients with autoimmune thyroid diseases. Problems of Endocrinology. 1998;44(4):22-24. (In Russ.) https://doi.org/10.14341/probl11568
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