The effect of an aromatase inhibitor on the level of estrogen in the blood of postmenopausal women
https://doi.org/10.14341/probl11570
Abstract
Effect of Femar, an imidasole inhibitor of aromatase, in a daily dose of 0.25 mg orally for 2 days, on blood estradiol is assessed in 16 menopausal women. The mean decrease of estradiol was 49.8%; this decrease was more pronounced in probands with Ketle ’s index of >30 or more than 40 kg of fat in the body in comparison with women with lower values. Gonadotropin (FSH and LH) concentrations in the blood were not much changed by femar. Possible mechanisms of endocrine changes and factors determining the sensitivity to aromatase inhibitors in vivo during the menopause are discussed.
About the Authors
L. M. BershteinResearch Institute of Oncology named after Acad. N. N. Petrova
Russian Federation
M. L. Gershanovich
Research Institute of Oncology named after Acad. N. N. Petrova
Russian Federation
V. B. Gamayunova
Research Institute of Oncology named after Acad. N. N. Petrova
Russian Federation
E. V. Tsyrlina
Research Institute of Oncology named after Acad. N. N. Petrova
Russian Federation
G. P. Loskutova
Research Institute of Oncology named after Acad. N. N. Petrova
Russian Federation
N. N. Blinov
Research Institute of Oncology named after Acad. N. N. Petrova
Russian Federation
S. Ya. Maksimov
Research Institute of Oncology named after Acad. N. N. Petrova
Russian Federation
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Review
For citations:
Bershtein L.M., Gershanovich M.L., Gamayunova V.B., Tsyrlina E.V., Loskutova G.P., Blinov N.N., Maksimov S.Ya. The effect of an aromatase inhibitor on the level of estrogen in the blood of postmenopausal women. Problems of Endocrinology. 1998;44(4):29-31. (In Russ.) https://doi.org/10.14341/probl11570
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