Effect of substitute estrogen therapy on phytoestrogen excretion

Abstract

Sixteen women were treated with estradiol valeriate (progynova) in a daily dose of 2 mg during 30 days for moderate menopausal vasomotor symptoms. The mean age of the patients was 55.3+1.15 years, duration of menopause 5.6 ± 0.8 years, body weight 68.0 + 3.0 kg, and height 161 ± 1.4 cm. Urinary phytoestrogen profiles (8 metabolites) were evaluated by isotope dilution capillary gas chromatography - mass spectrometry. Estrogen-replacing therapy (ERT) of menopausal patients led to redistribution of urinary excretion оf phytoestrogens at the expense of relative predominance of lignanes (enterolactione and enterodiol) over isoflavonoids (daidseine, henisteine). After ERT course the excretion of methoxyestrogens correlated positively with lignane excretion and negatively with isoflavonoid excretion. These changes may be important for secondary modification of clinical and endocrine effects of ERT.