Aldosterone secretion in Icenko-Cushing disease and its role in the development of hypertension
https://doi.org/10.14341/probl11679
Abstract
Daily changes in aldosterone secretion and its mean daily blood level were studied in patients with Icenko-Cushing disease with and without arterial hypertension and the relationship between aldosterone secretion, plasma renin activity, and blood hydrocortisone and ACTH level in such patients were studied. Two groups of patients with Icenko-Cushing disease were examined: with and without pronounced hypertension. Serum aldosterone, hydrocortisone, ACTH, and plasma renin activity were radioimmunoassayed simultaneously. Blood samples were collected at 8.00, 16.00, and 23.00, and the mean concentrations of hormones were calculated. Increase of hydrocortisone secretion was paralleled by increased secretion of aldosterone. Daily time course of blood aldosterone concentrations in patients with Icenko-Cushing disease complicated by hypertension was paradoxical: they were maximum in the evening and night hours. Development of hypertension in patients with Icenko-Cushing disease was closely associated with the duration and severity of disease and patient’s age.
About the Authors
N. P. GoncharovEndocrinology Research Centre, RAMS
Russian Federation
G. S. Kolesnikova
Endocrinology Research Centre, RAMS
Russian Federation
T. N. Todua
Endocrinology Research Centre, RAMS
Russian Federation
L. Ya. Rozhinskaya
Endocrinology Research Centre, RAMS
Russian Federation
Ye. I. Marova
Endocrinology Research Centre, RAMS
Russian Federation
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Review
For citations:
Goncharov N.P., Kolesnikova G.S., Todua T.N., Rozhinskaya L.Ya., Marova Ye.I. Aldosterone secretion in Icenko-Cushing disease and its role in the development of hypertension. Problems of Endocrinology. 2001;47(5):24-28. (In Russ.) https://doi.org/10.14341/probl11679
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