Evaluation of the growth-regulating system and use the recombinant growth hormone (genotropin) in children with rheumatic diseases and growth impairments on long-term glucocorticosteroid therapy
https://doi.org/10.14341/probl11716
Abstract
The paper presents the results of an investigation of the growth - regulating system (STH - insulin-like growth factor 1 - peripheral tissues) in 39 children with rheumatic diseases on longterm continuous glucocorticosteroid therapy. Of them, 6 patients received recombinant growth hormone (R-GH) (Genotropin) for correction of steroidal growth retardation. Twelve-month r-GH therapy made it possible not only to accelerate growth rates, but contributed to diminished manifestations of drug-induced hypercorticism without exerting a significant impact in the course of the underlying disease.
About the Authors
A. A. SharovaI. M. Sechenov MMA; Endocrinology Research Center of RAMS
Russian Federation
N. N. Volevodz
I. M. Sechenov MMA; Endocrinology Research Center of RAMS
Russian Federation
V. A. Peterkova
I. M. Sechenov MMA; Endocrinology Research Center of RAMS
Russian Federation
References
1. Дедов И. И., Тюльпанов АН., Петеркова В. А. Соматотропная недостаточность. - М., 1998. - С. 38-43.
2. Насонова В. А., Астапенко М. Г. Клиническая ревматология: Руководство для врачей. - М., 1989. - С. 142-143.
3. Розен В. Б. // Основы эндокринологии. - 3-е изд. - М., 1994. - С. 241-257.
4. Таннер Дж. // Биология человека / Под ред. Дж. Харрисона и др.: Пер. с англ. - М., 1979. - С. 306-471.
5. Allen D. В. // Endocrinol. Metab. Clin. N. Am. - 1996. - Vol. 25, N 3. - P. 699-717.
6. Allen D. B. // Endocrinologist. - 1998. - Vol. 8, N 1. - P. 21-30.
7. Allen D. B., Julius J. R., Breen T. J., Attie К. M. // J. Clin. Endocrinol. Metab. - 1998. - Vol. 83. - P. 2824-2829.
8. Bechtold S., Rippeiger P., Miihlbayer D. et al. // Ibid. - 2001. - Vol. 86, N 12. - P. 5737-5744.
9. Boguszewzki M. C. S., Figueiredo В C., Boguszewzki C. L. et al. I/ GH and Growth Factors in Endocrinology and Metabolism: Programme and Poster Abstracts of the 25-th International Symposium. - Istambul, 1998. - P. 122.
10. Bowers C. Y. // J. Pediatr. Endocrinol. - 1993. - Vol. 6, N 1.
Review
For citations:
Sharova A.A., Volevodz N.N., Peterkova V.A. Evaluation of the growth-regulating system and use the recombinant growth hormone (genotropin) in children with rheumatic diseases and growth impairments on long-term glucocorticosteroid therapy. Problems of Endocrinology. 2002;48(6):30-35. (In Russ.) https://doi.org/10.14341/probl11716
Views:
2060
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0).
Email this article 
.jpg){kind=logo}
