The effects of coordination zinc compound on glucose uptake and the activity of tissue pyruvate dehydrogenase in rats with experimental diabetes mellitus
https://doi.org/10.14341/probl11730
Abstract
Zinc compounds were examined for their effects on the transport of glucose through the membrane and on the activity of pyruvate dehydrogenase of mitochondria of the hearts and skeletal muscles from rats with experimental diabetes mellitus. The objects of the investigations were the rat diaphragm, cardiac and skeletal muscle mitochondria.
The aim of the investigation was to study the effect of the coordination zinc compound piracine on the transport of glucose in the diaphragm and on the activity of pyruvate dehydrogenase of the hearts and skeletal muscles from rats with experimental diabetes mellitus.
Experimental diabetes mellitus was induced by intraperitoneal alloxan hydrate during fasting.
The investigation established that piracine exerted a stimulating effect on glucose transport in experimental diabetes. With the coordination zinc compound, there was an increase in the activity of pyruvate dehydrogenase, which is lowered in diabetes.
The findings provide again evidence for the role of zinc ions in glucose transport and oxidation.
About the Authors
A. A. SamigzhonovInstitute of Biochemistry, Academy of Sciences of the Republic of Uzbekistan
Uzbekistan
M. Zh. Ergasheva
Institute of Biochemistry, Academy of Sciences of the Republic of Uzbekistan
Uzbekistan
T. S. Saatov
Institute of Biochemistry, Academy of Sciences of the Republic of Uzbekistan
Uzbekistan
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Review
For citations:
Samigzhonov A.A., Ergasheva M.Zh., Saatov T.S. The effects of coordination zinc compound on glucose uptake and the activity of tissue pyruvate dehydrogenase in rats with experimental diabetes mellitus. Problems of Endocrinology. 2002;48(6):48-50. (In Russ.) https://doi.org/10.14341/probl11730
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