Neuroendocrine mechanisms responsible for experimental anovulation of hyperandrogenie origin
https://doi.org/10.14341/probl11732
Abstract
An experimental model of anovulatory infertility of hyperandrogenic origin (subcutaneous implantation of silastic capsules with testosterone to mature female rats) was used to study morphological, hormonal, and biochemical indices that characterize the hypothalamic-pituitary-ovarian system. Disorders found in the functional metabolism of androgens in the hypothalamus, decreased pituitary response to hypothalamic hormone (HH), changes in the pattern of estrous cycles, ovarian morphological changes suggest that there are neuroendocrine disturbances ovulation regulation. The use of flutamide as a drug of experimental antiandrogenic therapy led to a partial normalization of hormonal, biochemical, and morphological characteristics and to recovery of fertility in female rats with anovulatory fertility.
About the Authors
A. G. ReznikovV.P. Komissarenko Institute of Endocrinology and Metabolism of the Academy of Medical Sciences of Ukraine
Ukraine
P. V. Sinitsyn
V.P. Komissarenko Institute of Endocrinology and Metabolism of the Academy of Medical Sciences of Ukraine
Ukraine
L. V. Tarasenko
V.P. Komissarenko Institute of Endocrinology and Metabolism of the Academy of Medical Sciences of Ukraine
Ukraine
L. I. Polyakova
V.P. Komissarenko Institute of Endocrinology and Metabolism of the Academy of Medical Sciences of Ukraine
Ukraine
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Review
For citations:
Reznikov A.G., Sinitsyn P.V., Tarasenko L.V., Polyakova L.I. Neuroendocrine mechanisms responsible for experimental anovulation of hyperandrogenie origin. Problems of Endocrinology. 2002;48(6):50-53. (In Russ.) https://doi.org/10.14341/probl11732
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