Thyroid function in pregnant females carrying thyroid peroxidase antibodies
https://doi.org/10.14341/probl11734
Abstract
То define risk factors for gestational hypothyroxinemia in females carrying thyroid peroxidase antibodies (TPO Ab) during pregnancy, a study was performed, which included 73 females at different periods of pregnancy in accordance with the following criteria: the lack of impaired dysfunction of the thyroid gland (TG) on primary examination; elevated TPO Ab levels (more than 100 mEU/l; no history of TG pathology. The control group comprised 128 pregnant females without TG pathology. Evaluation of TG function in females with TPO Ab who received and did not the physiological doses of iodine revealed that the function did not differ by the end of pregnancy. The odds ratio for hypothyroxinemia in pregnant females with more than 100 mEU/l of TPO Ab was 3.14. In a subgroup of females with TPO Ab and the enlarged TG in the second trimester, the level of fT4 was significantly lower and that of thyroid-stimulating hormone (TSH) was significantly higher than those in the control group. Logistic regression analysis indicated that a relatively high level of TSH in early gestation was most significant in females with TPO Ab. It is concluded that it is expedient to consider whether preventive levothyroxine therapy is performed in females who carry TPO Ab with the enlarged TG and with TSH level that is relatively high (more than 2 mMe/l) for early pregnancy.
About the Authors
V. V. FadeyevMoscow Medical Academy I.M. Sechenova
Russian Federation
S. V. Lesnikova
Moscow Medical Academy I.M. Sechenova
Russian Federation
G. A. Melnichenko
Moscow Medical Academy I.M. Sechenova
Russian Federation
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Review
For citations:
Fadeyev V.V., Lesnikova S.V., Melnichenko G.A. Thyroid function in pregnant females carrying thyroid peroxidase antibodies. Problems of Endocrinology. 2003;49(5):23-29. (In Russ.) https://doi.org/10.14341/probl11734
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