The effect of metformine and maninil on lipid metabolism in patients with type 2 diabetes
https://doi.org/10.14341/probl11846
Abstract
Effects of metformine and maninil on lipid metabolism and its hormonal regulators were studied in 38 patients with non-insulin-dependent diabetes mellitus (N1DDM) aged 35-55 years. A 3-month metformine course in a daily dose of 0.85 g notably decreased lipid content in the plasma, particularly of triglycerides (TG) and very low density lipoproteins. Monotherapy with metformine decreased basal and stimulated insulin secretion and glycaemia, and normalized GH secretion. Medium-expressed correlation between the extent of TG decrease and GH increase in the plasma was detected. Metformine did not change tissue respiration parameters in patients with initially normal lactate content. Despite diabetes compensation by glycaemia, lipid metabolism did not improve, insulin concentrations did not decrease, and GH did not normalize in NIDDM patients treated with maninil (0.005-0.015 g/day) during the same period.
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Review
For citations:
Davydov A.L. The effect of metformine and maninil on lipid metabolism in patients with type 2 diabetes. Problems of Endocrinology. 2000;46(3):10-13. (In Russ.) https://doi.org/10.14341/probl11846
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