Leptin content in men with androgen deficiency and obesity
https://doi.org/10.14341/probl11857
Abstract
The level of leptin production was measured in relation to the concentrations of adrenal androgens, testosterone, and gonadotropins in patients with various disorders of the male reproductive system and obesity. LH, FSH, prolactin, testosterone, estradiol, hydrocortisone, dihydroepiandrosterone (DHEA) and DHEA sulfate were radioimmunoassayed and leptin was measured by enzyme immunoassay. Body weight index (ВИД) in 66 examined patients varied from 20 to 40 kg/m2 and leptin content from 0.8 to 106 ng/ml. In general, the level of leptin directly correlated with the levels of BWI, LH, FSH, and DHEA sulfate and inversely with testosterone level. The highest levels of leptin were observed in patients with obesity combined with androgenic insufficiency, while in patients with obesity or androgenic insufficiency alone leptin levels were lower. No significant differences in leptin concentrations in relation to gonadotropin levels were detected. Normal fluctuations in the levels of adrenal androgens did not affect leptin production. These data indicate a possible involvement of testosterone in regulation of leptin production.
About the Authors
N. P. GoncharovEndocrinology Research Center RAMS
Russian Federation
M. V. Koryakin
Endocrinology Research Center RAMS
Russian Federation
G. V. Katsiya
Endocrinology Research Center RAMS
Russian Federation
G. S. Kolesnikova
Endocrinology Research Center RAMS
Russian Federation
A. D. Dobracheva
Endocrinology Research Center RAMS
Russian Federation
T. N. Todua
Endocrinology Research Center RAMS
Russian Federation
References
1. Панков Ю. А // Биохимия. — 1996. — Т. 61, №6. — С. 984-992.
2. Роув П. Дж., Комхаер Ф. X., Хагриив Т. Б., Милоуз X. Дж. // Руководство ВОЗ по стандартизированному обследованию и диагностике бесплодных супружеских пар: Пер. с англ. — М.. 1997.
3. Ahuna R. S., Prabakaran D., Mantzoros C. et al. // Nature. — 1996. Vol. 382. P. 250-255.
4. Bliasin S.. Storer T., Berman N. et al. // New Engl. J Med. — 1996. Vol. 335. P. 1-7.
5. Chekab F. E, Lim M. E., Lu R. // Nature Genet. — 1996. — Vol. 12. P. 318-320.
6. Compfield L. A., Smith F. J., Guisez Y. et al. // Science. — 1995. Vol. 269. P. 546-549.
7. Considine R И. Sinha M. K.. Heiman M. L. et al. // New Engl. J. Med. 1996. Vol. 334. P. 292-295.
8. Freeman M. E. // Endocrinology. — 1993. — Vol. 133. — P. 2411-2412.
9. Garcia-Mayor R. И, Andrade M. A., Rios M. et al. // .1. Clin. Endocrinol. 1997. Vol. 82. P. 2849-2855.
10. Goncharov N. P., Kolesnikova G. S., Vorontsov V. I. et al. // Proceedings of the 5-th Syntp. on the Analysis of Steroids. — Czombathly, 1993. — P. 407—426.
11. Hiroaki Masuzaki, Yoshihiro Ogawa, Kiminori Hosoda et al. // J.Clin. Endocrinol. 1997. Vol. 82. P. 2542-2547.
12. Hovel P. J., Kasim-Karrakos S., Dubuc G. R. et al. // Nature Med. 1996. Vol. 2. P. 949-950.
13. Jockenhovel F., Blum W. E. Vogel E. et al. // J. Clin. Endocrinol. 1997. Vol. 82. P. 2510-2513.
14. Kalra S. P.. Kalra P. S., Sahu A., Crowley W. R. // J Steroid Biochem. 1987. Vol. 27. P. 977-981.
15. Mantzoros Ch. S., Flier J. S., Rogol A. D. // J. Clin. Endocrinol. 1997. Vol. 82. P. 1066-1070.
16. Masuzaki H., Ogava Y.. Isse N. et al. // Diabetes. — 1995. — Vol. 44. P. 855-858.
17. Murakone T, lida M.. Shima K. // Biochem. Biophys. Res. Commun. — 1995. — Vol. 214. — P. 1260—1267.
18. Pelleymounter M. A., Cullen M. J.. Baker M. В et al. // Science. 1995. Vol. 269. P. 540-543.
19. Sinha M. K., Ohanessian J. P.. Heiman M. L. et al. // J. Clin. Invest. 1996. Vol. 97. P 1344-1347.
20. Sjogren J. Li M.. Bjorntorp P. // Biochint. Biophys. Acta. — 1995. Vol. 1244. P. 117-120.
21. Slieker L. J., Sloap K. W., Surface P. L. et al. // J. Biol. Chem. 1996. Vol. 27. P. 5301-5304.
22. Stephens T. W., Basinski M., Bristow P. K. et a). // Nature. — 1995. Vol. 377. — P. 530-532.
23. Sufi S. В . Donaldson A.. Jejfcoute S. L WHO Matched Reagent Programme Method Manual. — 16-th Ed. — London. 1992.
24. World Health Organization. Laboratory Manual for the Examination of Human Semen and Sperm-Cervical Mucus Interaction. — 3-rd Ed. — Cambridge. 1992.
25. Zhang Y., Proenca R.. Maffei M. et al. // Nature. — 1994. — Vol 372. P. 425-432.
Review
For citations:
Goncharov N.P., Koryakin M.V., Katsiya G.V., Kolesnikova G.S., Dobracheva A.D., Todua T.N. Leptin content in men with androgen deficiency and obesity. Problems of Endocrinology. 2000;46(4):6-9. (In Russ.) https://doi.org/10.14341/probl11857
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