Immune mechanisms of development of diabetic nephropathy
https://doi.org/10.14341/probl11868
Abstract
Changes in the levels of circulating immunoglobulins and production of autoantibodies to basal membrane of renal glomeruli were studied in patients with insulin-dependent diabetes mellitus (IDDM) at various stages of diabetic nephropathy (DN). The number of patients with positive reaction to autoantibodies to renal basal membrane (R.BM) increases as clinical symptoms of DN augment. The greater part of patients with positive reaction to antibodies have stage 111-IV DN. Measurements of serum immunoglobulin concentrations in patients with DN of different degree showed maximal levels of IgG in initial IDDM (without DN); later IgG level gradually decreases, while IgM level shows a tendency to increase, this increase attaining statistically significant values in patients with pronounced nephropathy. In patients with antibodies to R.BM the ratios of IgG/IgD and IgM/IgD concentrations are elevated, while IgA/IgG and IgA/IgM ratios are lowered; only the IgG/IgD and IgA/IgG ratios differed significantly from the control. 26.8% patients with IDDM had antibodies to basal membrane of renal glomeruli. The number of patients with positive reaction to these antibodies increases with the progress of nephropathy, which can be indicative of the involvement of autoimmune mechanisms in development and progress of DN.
About the Authors
A. S. EfimovInstitute of Endocrinology and Metabolism V.P. Komissarenko of the Academy of Medical Sciences of Ukraine
Ukraine
D. Ch. Tajieva
Institute of Endocrinology and Metabolism V.P. Komissarenko of the Academy of Medical Sciences of Ukraine
Ukraine
I. N. Pishel
Institute of Endocrinology and Metabolism V.P. Komissarenko of the Academy of Medical Sciences of Ukraine
Russian Federation
References
1. Галенок В. А., Жук Е. А. // Пробл. эндокринол. — 1997. — Т. 43, № 3. С. 13-16.
2. Галенок В. А., Жук Е. А. // Тер. арх. — 1998. — № 10. — С. 5-10.
3. Дедов И. И., Мухин Н. А., Шестакова М. В. и др. // Пробл. эндокринол. — 1990. — Т. 36, № 4. — С. 57—63.
4. Ефимов А. С., Скробонская Н. А. Клиническая диабетология. — Киев, 1998.
5. Саложин К. В., Насонов Е. Л., Сура В. В. // Тер. арх. — 1991. Т. 63, № 6. С. 55-58.
6. Сура В. В., Камаева О. И. // Пробл. эндокринол. — 1996. № 3. С. 42-47.
7. Тронько М.Д., Сф'шов А. С., Кравченко В. I., Паныав В. I. — Киев, 1996.
8. Baynes I. W. // Diabetes. 1992. — Vol. 40, N 9. P. 405-412.
9. Forsblom С. M., Groop P. H., Ekstrand A. et al. // Diabetes Care. 1998. Vol. 21, N 11. P. 1932-1938.
10. Galtier-Dereure F., Biron C. Vies M., et al. // Lupus. — 1998.Vol. 7, N 7. P. 469-474.
11. Hayashi Y, Makino H., Shikata K. et al. // J. Diabet. Compl.1991. Vol. 5, N 2-3. P. 195-196.
12. Kim Y., Kleppel M. M., Butkowski R. et al. // Am. J. Pathol. — 1991. Vol. 138, N 2. P. 413-420.
13. Mancini G., Nash D. R., Heremans J. F. // Immunochemistry.1970. Vol. 7, N 2. P. 261-264.
14. Mogensen С. E., Christiensen С. K., Yittinghus E. // Diabetes.1983. Vol. 32, N 8. P. 64.
15. Ohmuro H., Tomino Y, Tsushima Y. et al. // Nephron. — 1993. Vol. 63, N 3. P. 355.
16. Rodriguez-Segade S., Camina M. F, Carnero A. et al. // Clin. Chem. 1996. Vol. 42, N 7. P. 1064-1067.
Review
For citations:
Efimov A.S., Tajieva D.Ch., Pishel I.N. Immune mechanisms of development of diabetic nephropathy. Problems of Endocrinology. 2000;46(5):6-10. (In Russ.) https://doi.org/10.14341/probl11868
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