The effect of vitamin E on the development of nephropathy in rabbits with dithizone diabetes
https://doi.org/10.14341/probl11884
Abstract
The effects of vitamin E (VE) on early-stage diabetic nephropathy were studied in experimental insulin-dependent diabetes mellitus. Absolute insulin deficiency was modelled with an intravenous injection of ditisone to male rabbits (35 mg/kg). Vitamin E (tocoferoli acetatas) was given orally as gelatin capsules, 100 mg per animal daily for 2 months. VE-fed rabbits exhibited a significant lowering of basal hyperglycemia, rise of basal insulinemia, and better glucose tolerance than diabetic control. VE also normalized ditisone-increased level of cholesterol, beta-lipoproteins and reduced concentrations of dienic conjugates in blood serum of the diabetic animals. Angioprotective effect of VE manifesting in lowering of microalbuminuria, mass of the kidney and thickness of basal glomerular membrane validates the efficiency of VE in prevention or attenuation of clinical nephropathy in patients with diabetes mellitus.
About the Authors
V. V. PoltorakUkrainian Research Institute of Pharmacotherapy of Endocrine Diseases
Ukraine
N. I. Gorbenko
Ukrainian Research Institute of Pharmacotherapy of Endocrine Diseases
Ukraine
A. I. Gladkikh
Ukrainian Research Institute of Pharmacotherapy of Endocrine Diseases
Ukraine
O. V. Ivanova
Ukrainian Research Institute of Pharmacotherapy of Endocrine Diseases
Ukraine
References
1. Гублер Е. В., Генкин А. А. Применение непараметрических критериев статистики в медико-биологических исследованиях. — Л., 1973.
2. Дженингс П. // Диабетография. — 1995. — № 3. — С. 22—24.
3. КайдинД. А. //Лаб. дело. 1973. № 12. С. 750-752.
4. Плацер 3., Видлакова М., Купила Л. // Чехосл. мед. обзор. 1970. Т. 10, № 1. С. 30-41.
5. Плохинский Н. А. Математические методы в биологии. — М., 1978.
6. Пушкарев И. А. Лабораторная диагностика протеинурии. — Рига, 1985.
7. Baumgart! Н., Banholzer Р.. Sigi С. et al. // Nephrol. Dial. Transplant. — 1998. — Vol. 13. — P. 630—634.
8. Baynes J. W. // Diabetes. — 1991. — Vol. 40. — P. 405—412.
9. Born J., Kraats A. A., Bakker M. A. et al. // Diabetologia. — Vol. 38. P. 1169-1175.
10. Coupland R., Davidson J., Lazarow A. // Anat. Res. — 1956. — Vol. 124. P. 394.
11. Graven P., Derubertis F., Kagan V. et al. // J. Am. Soc. Nephrol. 1997. Vol. 8. P. 1405-1414.
12. Hirose K, Osterby R., Nosova M. et al. // Kidney lilt. — 1982. Vol. 21. P. 689-695.
13. Ivanova O., Poltorack И, Gorbenko N., Gladkich A. // Diabctologia. — 1998. — Vol. 41, Suppl. 1. — P. 266.
14. Kakkar R., Mantha S., Radhi J. et al. // Life Sci. — 1997. — Vol. 60. P. 667-779.
15. Kennedy L. A., Lyons T. J. // Metabolism. — 1997. — Vol. 46, N 12. P. 14-21.
16. Mogensen С. E. // J. Intern. Med. — 1994. — Vol. 235. — P. 297-316.
17. Mogensen С. E. // Diabetologia. — 1999. — Vol. 42, N 3. — P. 263-286.
18. Okamoto K. // Folia Endocr. Jpn. — 1949. — Vol. 25, N 1. — P. 32-61.
19. Packer L., Witt E., Trischter H. // Free Radic. Biol. Med. — 1995. Vol. 19. P. 227-250.
20. Parving H. // Diabetologia. — 1998. — Vol. 41. — P. 745— 759.
21. Porte D., Schwartz M. // Science. — 1996. — Vol. 272. — P. 699-700.
Review
For citations:
Poltorak V.V., Gorbenko N.I., Gladkikh A.I., Ivanova O.V. The effect of vitamin E on the development of nephropathy in rabbits with dithizone diabetes. Problems of Endocrinology. 2000;46(6):41-44. (In Russ.) https://doi.org/10.14341/probl11884
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