Clinical and cytogenetic examinations of patients with transsexualism

Abstract

Patients with male and female transsexualism were examined using clinical, cytogenetic, gametological and morphological methods. All patients were shown to possess normal karyotype without disorders in chromosome number or structure. Signs of sclerocystic ovaries were detected in 25% of patients with female transsexualism before treatment; after androgen therapy of 1 to 3 years signs of sclerocystic ovaries and folliculogenesis suppression were observed in 100% cases. All the patients with male transsexualism presented with spermatogenesis in the form of oligoasthenoteratozoospermia and degeneration of immature sex cells before therapy.