Atherogenic characteristics of oral sugar-reducing sulfonylurea derivatives
https://doi.org/10.14341/probl11986
Abstract
The authors have examined the effects of sulfonylurea drugs glybenclamide and glypizide and of their analogs manilil and minidiab on cholesterol levels in murine peritoneal macrophages. Both glybenclamide and glypizide had a direct atherogenic effect on cultured murine peritoneal macrophages. A similar effect was observed in vivo: blood sera of diabetics after a single intake of 5 mg of manilil or minidiab increased the atherogenic potential of cultured murine peritoneal macrophages.
About the Authors
M. A. Maxumova
Endocrinology Research Centre; Cardiology Research Centre
Russian Federation
Russian Federation
I. A. Sobenin
Endocrinology Research Centre; Cardiology Research Centre
Russian Federation
Russian Federation
M. I. Balabolkin
Endocrinology Research Centre; Cardiology Research Centre
Russian Federation
Russian Federation
A. N. Orekhov
Endocrinology Research Centre; Cardiology Research Centre
Russian Federation
Russian Federation
References
1. Собенин И. А., Тертое В. В., Кошински Т. и др. // Кардиология.— 1991.— № 10.— С. 38—41.
2. Berger S. // Meth. Enzymol.— 1979.— Vol. 5.— P. 486—494.
3. Bradley R. F„ Dolger H. et al. // J. A. M. A.- 1975.- Vol. 232,— P. 813—827.
4. Hara A., Radin N. S. 11 Analyt. Biochem.— 1978.— Vol. 90.— P. 420.
5. Lowry О. H., Rosebrough N. J., Farr A. L., Randall R. J. 11 J. biol. Chem.— 1951.— Vol. 193.-P. 265.
6. Melander A., Bitzen P. O., Faber O. et al. // Drugs.— 1989,— Vol. 37,— P. 58—72.
7. Peterson С. M., Sims P. V., Jones R. L. // Diabet. Care.— 1982,- Vol. 5,- P. 497.
8. Slavina E. S., Madanat A. Ya., Syrkin A. L. et al. // New Engl. J. Med.— 1987,— Vol. 317.— P. 836.
9. Tertov V. V., Orekhov A. N., Nikitina N. A. et al. // Ann. Med.— 1989.— Vol. 21.— P. 455—459.
10. University Group Diabetes Program // Diabetes.— 1970.— Suppl. 2,— P. 787—830.
11. Whitehouse F. W., Arky R. A., Bell D. I. et al. // Ibid.—1978 — Vol. 28,— P. 168—170.
Review
For citations:
Maxumova M.A., Sobenin I.A., Balabolkin M.I., Orekhov A.N. Atherogenic characteristics of oral sugar-reducing sulfonylurea derivatives. Problems of Endocrinology. 1994;40(3):8-10. (In Russ.) https://doi.org/10.14341/probl11986
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