KIGS demographic studies

Abstract

The eighth kigs report (international growth study by Kabi Pharmacy) is based on an analysis of the treatment outcomes of 7,083 children from 18 countries. Of these, 3380 had idiopathic growth hormone deficiency (IGN), 1111 - IGN due to organic lesions and 2592 - other causes of stunting. All the children were at different schemes of injection of growth hormone. The duration of treatment in idiopathic DISEASE averaged 3.5 years, in organic disorders-4 years, with other types of stunting-3.3 years. At the beginning of treatment, all children had low growth: -2.7 SDS (Tanner standards) in idiopathic GAMES, -2.2 SDS in organic GAMES (-1.75 SDS in brain tumors, -1.8 SDS in leukemia), -2.9 SDS with other types of stunting. The average age of children in all groups before treatment was about 10 years. The growth rate before treatment was low compared to healthy children of the same age. In most cases (95 %) growth hormone treatment was carried out daily or 6 times a week, while the dose of the hormone administered in different countries varied significantly (from 0.4 to 0.7 u/kg per week). Subsequent analysis of the KIGS database will help to see how these differences will affect growth rates and the end result of treatment.