Contribution of cow milk proteins to the development of insulin-dependent diabetes mellitus in children
https://doi.org/10.14341/probl12050
Abstract
In the last decade, data have appeared in the literature, obtained mainly by researchers from Canada and Finland, due to which a new direction has been outlined in the study of the mechanism of development of insulin-dependent diabetes mellitus (IDDM) in children. The results of these studies revealed the effect of cow's milk proteins (CMP), which were ingested by the child during the neonatal period, on the development of later IDDM, namely, the trigger (trigger) role of the antigenic structures of some CMPs in autoimmune damage to pancreatic p-cells in genetically predisposed individuals. Based on the obtained experimental and clinical data, it can be assumed that in order to prevent the development of IDDM in children with an increased risk of developing this disease who are on artificial or mixed feeding, it is advisable to use products based on CMP hydrolysates devoid of antigenic properties or soy proteins, similar to already known hypoallergenic mixtures. Targeted selection of newborns in need of specialized nutrition, in our opinion, is possible by conducting certain diagnostic tests aimed at identifying children with an increased risk of sensitization with CMP antigens.
About the Authors
L. I. Shirina
Institute of Nutrition of the RAMS
Russian Federation
Russian Federation
V. K. Maso
Institute of Nutrition of the RAMS
Russian Federation
Russian Federation
V. V. Vysotskaya
Institute of Nutrition of the RAMS
Russian Federation
Russian Federation
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Review
For citations:
Shirina L.I., Maso V.K., Vysotskaya V.V. Contribution of cow milk proteins to the development of insulin-dependent diabetes mellitus in children. Problems of Endocrinology. 1996;42(6):8-14. (In Russ.) https://doi.org/10.14341/probl12050
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