Time course of the cellular and humoral immunity parameters in patients with type I diabetes mellitus
https://doi.org/10.14341/probl12179
Abstract
Fifty-two patients with type I diabetes mellitus were examined. The patients were divided into 4 groups with various duration of the disease: group 1 included patients with the newly diagnosed disease, group 2 those with disease standing of 1 to 5 years, group 3 were patients suffering from diabetes for 6 to 10 years, and group 4 were diabetics for 10 years and more. The parameters examined were antibodies to surface antigens of islet cells, absolute and relative counts of T and В lymphocytes in the peripheral blood, counts of T-helpers and T-suppressors and cytotoxic cells and their ratios, counts of natural killers, DR (+) and IgG (+) cells, and basal C- peptide level. The results showed a correlation between autoantibodies to surface antigens of islet cells and the count of В lymphocytes, an inversion of T lymphocyte subpopulations, with the helper/sup- pressor index increased at the initial stages of the disease and decreasing with the disease progress.
About the Authors
V. V. Potyomkin
Russian State Medical University
Russian Federation
Russian Federation
T. V. Nikonova
Russian State Medical University
Russian Federation
Russian Federation
S. V. Brykova
Russian State Medical University
Russian Federation
Russian Federation
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Review
For citations:
Potyomkin V.V., Nikonova T.V., Brykova S.V. Time course of the cellular and humoral immunity parameters in patients with type I diabetes mellitus. Problems of Endocrinology. 1994;40(6):5-7. (In Russ.) https://doi.org/10.14341/probl12179
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