Transient hyperinsulinism in neonates
Anna V. Bolmasova,
Maria A. Melikyan,
Natalya A. Krylova,
Oleg V. Ionov,
Irina I. Ryumina,
Ekaterina L. Bockeria,
Natalya A. Pekareva,
Anna V. Degtyareva https://doi.org/10.14341/probl12572
Abstract
Congenital hyperinsulinusm is rare disease characterized high secretion of insulin by pancreatic beta cells leading to the development of hypoglycemia. Persistent and transient forms of hyperinsulinism are distinguished. Transient hyperinsulinism are the most common cause of severe hypoglycemia in newborns. The etiology of this disease is not known. There are risk factors for the development of transient hyperinsulinism: asphyxia at birth, prematurity, maternal diabetes, low or large weight by gestation. Hypoglycemia with hyperinsulinism is severe. Therefore, early diagnosis and therapy especially during the neonatal period, are necessary.
The article describes 3 clinical cases of transient hyperinsulinism in children with different gestational age and concomitant pathology. All children recevied insulinostatic therapy with diazoxide with a positive effect: euglycemia without glucose requirement . In all children, therapy was completed subsequently. At the time of publication of the article, the physical and psychomotor development of children is normal.
About the Authors
Anna V. Bolmasova
Kulakov Federal Rеseаrch Center for Obstetrics, Gynecology and Perinatology; Endocrinology research Centre
Russian Federation
Russian Federation
MD, PhD; ORCID: orcid.org/0000-0003-3127-5974, eLibrary SPIN: 7843-1604
4, Oparin street, Moscow
Maria A. Melikyan
Kulakov Federal Rеseаrch Center for Obstetrics, Gynecology and Perinatology
Russian Federation
Russian Federation
MD, PhD; ORCID: 0000-0002-1491-2460; eLibrary SPIN: 4184-4383
Moscow
Natalya A. Krylova
Kulakov Federal Rеseаrch Center for Obstetrics, Gynecology and Perinatology
Russian Federation
Russian Federation
MD; ORCID: 0000-0002-3788-0887; eLibrary SPIN: 6289-2376
Moscow
Oleg V. Ionov
Kulakov Federal Rеseаrch Center for Obstetrics, Gynecology and Perinatology
Russian Federation
Russian Federation
MD, PhD; ORCID: 0000-0002-4153-133X; eLibrary SPIN: 3492-6281
Moscow
Irina I. Ryumina
Kulakov Federal Rеseаrch Center for Obstetrics, Gynecology and Perinatology
Russian Federation
Russian Federation
MD, PhD prof; ORCID: 0000-0003-1831-887X; eLibrary SPIN: 1054-8996
Moscow
Ekaterina L. Bockeria
Kulakov Federal Rеseаrch Center for Obstetrics, Gynecology and Perinatology
Russian Federation
Russian Federation
MD, PhD prof; ORCID: 0000-0002-8898-961; eLibrary SPIN: 7367-6290
Moscow
Natalya A. Pekareva
Kulakov Federal Rеseаrch Center for Obstetrics, Gynecology and Perinatology
Russian Federation
Russian Federation
MD, PhD; ORCID: 0000-0002-6931-9672, eLibrary SPIN: 5304-2544
Moscow
Anna V. Degtyareva
Kulakov Federal Rеseаrch Center for Obstetrics, Gynecology and Perinatology
Russian Federation
Russian Federation
MD, PhD prof; ORCID: 0000-0003-0822-751X, eLibrary SPIN: 2361-9978
Moscow
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For citations:
Bolmasova A.V., Melikyan M.A., Krylova N.A., Ionov O.V., Ryumina I.I., Bockeria E.L., Pekareva N.A., Degtyareva A.V. Transient hyperinsulinism in neonates. Problems of Endocrinology. 2020;66(4):61-67. (In Russ.) https://doi.org/10.14341/probl12572
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