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Роль глюкозы и инсулина в метаболической регуляции секреции гормона роста

https://doi.org/10.14341/probl12660

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Аннотация

Точные физиологические основы подавления секреции гормона роста пероральным приемом глюкозы на сегодняшний день остаются неизвестными, несмотря на широкое применение перорального глюкозотолерантного ­теста в эндокринологии. Отсутствие подавления гормона роста глюкозой встречается примерно у трети пациентов с акромегалией, а также при других расстройствах. В настоящее время известно, что на секрецию гормона роста воздействуют различные факторы, такие как возраст, пол, индекс массы тела и перераспределение жировой ткани. Также появляются данные о влиянии на секрецию гормона роста не только избыточной массы тела, но и переедания. Как ­известно, оба этих состояния связаны с гиперинсулинемией, что определяет возможность ее преимущественной роли в подавлении секреции гормона роста. Целью данного обзора является обсуждение накопленных данных об изолированном влиянии на секрецию гормона роста гипергликемии и гиперинсулинемии, а также других метаболических регуляторов и состояний, влияющих на его сигналинг. Понимание патофизиологических основ этих механизмов необходимо для дальнейших исследований роли глюкозы и инсулина в метаболической регуляции секреции гормона роста. При этом важно учитывать, что исследования на животных моделях затруднены межвидовыми различиями в ответе гормона роста на нагрузку глюкозой, и единственной возможной доступной моделью у здоровых людей авторам представляется использование гиперинсулинемического эугликемического клэмп-теста.

 

Об авторах

Е. Л. Соркина
Национальный медицинский исследовательский центр эндокринологии

Соркина Екатерина Леонидовна, кандидат медицинских наук, старший научный сотрудник лаборатории клэмп-технологий отдела прогнозирования и инноваций института диабета,
доцент кафедры эндокринологии

Москва

eLibrary SPIN: 7777-0248



В. В. Чичкова
Национальный медицинский исследовательский центр эндокринологии
Россия

Чичкова Валентина Валерьевна, клинический ординатор

117036, Москва, ул. ДмУльянова, д. 11

eLibrary SPIN: 9386-8320



И. А. Скляник
Национальный медицинский исследовательский центр эндокринологии

Скляник Игорь Александрович, научный сотрудник

Москва

eLibrary SPIN: 7081-8077



М. В. Шестакова
Национальный медицинский исследовательский центр эндокринологии

Шестакова Марина Владимировна, доктор медицинских наук, профессор, академик РАН

Москва

eLibrary SPIN: 7584-7015



Г. А. Мельниченко
Национальный медицинский исследовательский центр эндокринологии

Мельниченко Галина Афанасьевна, доктор медицинских наук, профессор, академик РАН

Москва

eLibrary SPIN: 5873-2280



А. Баркан
Мичиганский университет
Соединённые Штаты Америки

Баркан Ариэль, доктор медицинских наук, профессор медицины и нейрохирургии, cодиректор Центра нейроэндокринологии и заболеваний гипофиза Мичиганского университета

Энн-Арбор



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1. Рисунок 1. Модель физиологической регуляции секреции гормона роста (адаптировано из [19])
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Соркина Е.Л., Чичкова В.В., Скляник И.А., Шестакова М.В., Мельниченко Г.А., Баркан А. Роль глюкозы и инсулина в метаболической регуляции секреции гормона роста. Проблемы Эндокринологии. 2021;67(1):52-59. https://doi.org/10.14341/probl12660

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Sorkina E.L., Chichkova V.V., Sklyanik I.A., Shestakova M.V., Mel'nichenko G.A., Barkan A. The role of glucose and insulin in the metabolic regulation of growth hormone secretion. Problems of Endocrinology. 2021;67(1):52-59. https://doi.org/10.14341/probl12660

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ISSN 0375-9660 (Print)
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