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Preparation of the dialysis patient with type 1 diabetes mellitus for kidney transplantation

https://doi.org/10.14341/probl12686

Abstract

Kidney transplantation is unique method of renal replacement therapy, allowing to improve quality and duration of life for patients with diabetes mellitus type 1 (DM1) and end-stage renal disease (ESRD) on dialysis therapy. Recently using of innovation technologies for diabetes management and modern immunosuppression enable achieving better results of posttransplant rehabilitation for patients with DM1, especially if kidney transplantation is performed early after initiation of dialysis. Detailed examination of patient with DM1 before potential kidney transplantation is very important to reduce of early and late postoperative complications. Kidney transplantation preparation includes effective glycemic control, adequate dialysis therapy, treatment of diabetes and ESRD complications and concomitant conditions, especially cardiovascular diseases, accounting for kidney transplantation perspective. Furthermore, diagnostics and treatment of any infectious process, timely vaccination, cancer screening are basic approaches of kidney transplantation preparation program, providing the best survival rate of kidney graft and patient.

About the Authors

S. A. Martynov
Endocrinology Research Centre
Russian Federation

Sergey A. Martynov - MD, PhD.
11 Dm Ulyanova str., 117036, Moscow.
eLibrary SPIN: 6231-2450


Competing Interests: No


A. S. Severina
Endocrinology Research Centre
Russian Federation

Anastasia S. Severina - MD, PhD, leading research associate.
11 Dm Ulyanova str., 117036, Moscow.
eLibrary SPIN: 3182-9510


Competing Interests: No


I. I. Larina
Endocrinology Research Centre
Russian Federation

Irina I. Larina - MD, research associate.
11 Dm Ulyanova str., 117036, Moscow.
eLibrary SPIN: 1220-6080


Competing Interests: No


M. S. Shamhalova
Endocrinology Research Centre
Russian Federation

Minara S. Shamhalova - MD, PhD.
11 Dm Ulyanova str., 117036, Moscow.
eLibrary SPIN: 4942-5481


Competing Interests: No


S. V. Arzumanov
N.A. Lopatkin Research Institute of Urology and Interventional Radiology — branch of the National Medical Radiological Research Centre
Russian Federation

Sergey V Arzumanov - MD, PhD.
Moscow.
eLibrary SPIN: 8317-3723


Competing Interests: No


A. V. Pinchuk
Sklifosovsky Research Institute for Emergency Medicine
Russian Federation

Aleksey V. Pinchuk - MD, PhD.
Moscow.
eLibrary SPIN: 8875-2456


Competing Interests: No


M. V. Shestakova
Endocrinology Research Centre
Russian Federation

Marina V. Shestakova - MD, PhD, Professor.
11 Dm Ulyanova str., 117036, Moscow.
eLibrary SPIN: 7584-7015


Competing Interests: No


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Supplementary files

1. Figure 1. Survival of patients with intact renal transplant function (873 people; LT), patients who started dialysis after the loss of a kidney transplant (273 people; LT-D), and patients on dialysis (1273 people; D ), since the start of dialysis treatment (assessed by Kaplan – Meier) [13].
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Type Исследовательские инструменты
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2. Figure 2. Relative risk (95% CI) of inadequate renal graft function without death from any cause (A), mortality of recipients from any cause (B), inadequate renal graft function without cardiovascular mortality (C) and inadequate renal graft function without fatalities outcome (D) depending on the mean HbA1c value before kidney transplant in 2872 dialysis patients with diabetes mellitus followed up for 6 years after kidney transplantation (Cox regression analysis) [27].
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Type Исследовательские инструменты
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For citations:


Martynov S.A., Severina A.S., Larina I.I., Shamhalova M.S., Arzumanov S.V., Pinchuk A.V., Shestakova M.V. Preparation of the dialysis patient with type 1 diabetes mellitus for kidney transplantation. Problems of Endocrinology. 2020;66(6):18-30. (In Russ.) https://doi.org/10.14341/probl12686

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