Adipocytokines: modern definition, classification and physiological role
https://doi.org/10.14341/probl12805
Abstract
Adipose tissue is an endocrine organ which produces a large number of secretory bioactive substances also known as adipocytokines affecting directly insulin resistance (IR), glucose and lipid metabolism, angiogenesis and inflammation. The studies show a close connection between the imbalance of adipocytokines formed as a result of excessive deposit of adipose tissue in the course of the development of type 2 diabetes mellitus and cardiovascular diseases. In the present review, we summarize current data on the effect of the adipocytokines on the liver, skeletal muscles, adipose tissue, endothelial cells and inflammatory processes, as well as attempt to define the term «adipocytokines» and classify adipocytokines according to their influence on metabolic processes and pro-inflammatory status. Some of adipocytokines (adiponectin, omentin, leptin, resistin, tumor necrosis factor-α and interleukin-6) are divided into two groups: adipocytokines reducing IR, and adipocytokines increasing IR.
About the Authors
T. N. Markova
City Clinical Hospital №52;
Moscow State University of Medicine and Dentistry named after A.I. Evdokimov
Russian Federation
Russian Federation
Tatyana N. Markova, MD, PhD, Professor
3 Pehotnaja street, 123182 Moscow
N. K. Mishchenko
Moscow State University of Medicine and Dentistry named after A.I. Evdokimov
Russian Federation
Russian Federation
Nadezhda K. Mishchenko, PhD student, endocrinologist
Moscow
D. V. Petina
City Clinical Hospital №52
Russian Federation
Russian Federation
Diana V. Petina, endocrinologist
Moscow
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Markova T.N., Mishchenko N.K., Petina D.V. Adipocytokines: modern definition, classification and physiological role. Problems of Endocrinology. 2022;68(1):73-80. (In Russ.) https://doi.org/10.14341/probl12805
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