The impact of BMI on the course of the acute SARS-COV-2 infection and the risks that emerge during the first year after the hospital discharge. Subanalysis evidence of the AKTIV and AKTIV 2 registries
https://doi.org/10.14341/probl13165
Abstract
BACKGROUND. There is enough evidence of the negative impact of excess weight on the formation and progression of res piratory pathology. Given the continuing SARS-CoV-2 pandemic, it is relevant to determine the relationship between body mass index (BMI) and the clinical features of the novel coronavirus infection (NCI).
AIM. To study the effect of BMI on the course of the acute SARS-COV-2 infection and the post-covid period.
MATERIALS AND METHODS. AKTIV and AKTIV 2 are multicenter non-interventional real-world registers. The АКТИВ registry (n=6396) includes non-overlapping outpatient and inpatient arms with 6 visits in each. The АКТИВ 2 registry (n=2968) collected the data of hospitalized patients and included 3 visits. All subjects were divided into 3 groups: not overweight
(n=2139), overweight (n=2931) and obese (n=2666).
RESULTS. A higher BMI was significantly associated with a more severe course of the infection in the form of acute kidney injury (p=0.018), cytokine storm (p<0.001), serum C-reactive protein over 100 mg/l (p<0.001), and the need for targeted therapy (p<0.001) in the hospitalized patients. Obesity increased the odds of myocarditis by 1,84 times (95% confidence interval [CI]: 1,13–3,00) and the need for anticytokine therapy by 1,7 times (95% CI: 1,30–2,30).
The patients with the 1st and 2nd degree obesity, undergoing the inpatient treatment, tended to have a higher probability of a mortality rate. While in case of morbid obesity patients this tendency is the most significant (odds ratio — 1,78; 95% CI: 1,13-2,70). At the same time, the patients whose chronical diseases first appeared after the convalescence period, and those who had certain complaints missing before SARS-CoV-2 infection, more often had BMI of more than 30 kg/m2 (p<0,001).
Additionally, the odds of death increased by 2,23 times (95% CI: 1,05-4,72) within 3 months after recovery in obese people over the age of 60 years
CONCLUSION. Overweight and/or obesity is a significant risk factor for severe course of the new coronavirus infection and the associated cardiovascular and kidney damage Overweight people and patients with the 1st and 2nd degree obesity tend to have a high risk of death of SARS-CoV-2 infection in both acute and post-covid periods. On top of that, in case of morbid obesity patients this tendency is statistically significant. Normalization of body weight is a strategic objective of modern medicine and can contribute to prevention of respiratory conditions, severe course and complications of the new coronavirus infection.
About the Authors
A. G. ArutyunovRussian Federation
Alexander G. Arutyunov - MD, PhD, Professor
E. I. Tarlovskaya
Russian Federation
Ekaterina I. Tarlovskaya - MD, PhD, Professor
G. R. Galstyan
Russian Federation
Gagik R. Galstyan - MD, PhD, Professor
T. I. Batluk
Russian Federation
Tatiana I. Batluk - PhD
R. A. Bashkinov
Russian Federation
Roman A. Bashkinov
G. P. Arutyunov
Russian Federation
Gregory P. Arutyunov - MD, PhD, professor
Yu. N. Belenkov
Russian Federation
Yuri N. Belenkov - MD, PhD
A. O. Konradi
Russian Federation
Alexandra O. Konradi - MD, PhD, Professor
Yu. M. Lopatin
Russian Federation
Yury M. Lopatin - MD, PhD, Professor
A. P. Rebrov
Russian Federation
Andrey P. Rebrov - PhD, MD, Professor
S. N. Tereshchenko
Russian Federation
Sergey N. Tereshchenko - MD, PhD, Professor
A. I. Chesnikova
Russian Federation
Anna I. Chesnikova - MD, PhD, Professor
H. G. Hayrapetyan
Armenia
Hamlet G. Hayrapetyan - MD, PhD, Professor
A. P. Babin
Moldova, Republic of
Aleksandr P. Babin - MD, PhD, Associate Professor
I. G. Bakulin
Russian Federation
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Belgium
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Armenia
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Moldova, Republic of
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Uzbekistan
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References
1. Dedov II, Mokrysheva NG, Mel’nichenko GA, et al. Obesity. Clinical guidelines. Consilium Medicum. 2021;23(4):311-325. (In Russ.). doi: https://doi.org/10.26442/20751753.2021.4.200832.
2. gks.ru/free_doc/new_site/ food18/index.html [Internet]. Federal’naya sluzhba gosudarstvennoj statistiki. Vyborochnoe nablyudenie raciona pitaniya naseleniya (2018 g.). Statisticheskie tablicy; Rossijskaya Federaciya (in Russ.). Доступно по: https://rosstat.gov.ru/storage/mediabank/Racion.pdf. Ссылка активна на 30.08.2022.
3. Guh DP, Zhang W, Bansback N, et al. The incidence of comorbidities related to obesity and overweight: A systematic review and meta-analysis. BMC Public Health. 2009;9(1):88. doi: https://doi.org/10.1186/1471-2458-9-88
4. Dixon AE, Peters U. The effect of obesity on lung function. Expert Rev Respir Med. 2018;12(9):755-767. doi: https://doi.org/10.1080/17476348.2018.1506331.
5. Zuin M, Rigatelli G, Zuliani G, et al. Arterial hypertension and risk of death in patients with COVID-19 infection: Systematic review and meta-analysis. J Infect. 2020;81(1):e84-e86. doi: https://doi.org/10.1016/j.jinf.2020.03.059
6. Arutyunov GP, Tarlovskaya EI, Arutyunov AG, et al. ACTIV SARS-CoV-2 registry (Analysis of Chronic Non-infectious Diseases Dynamics After COVID-19 Infection in Adult Patients). Assessment of impact of combined original comorbid diseases in patients with COVID-19 on the prognosis. Terapevticheskii arkhiv. 2022;94(1):32-47. (In Russ.). doi: https://doi.org/10.26442/00403660.2022.01.201320
7. Arutyunov GP, Tarlovskaya EI, Arutyunov AG, et al. International register “Dynamics analysis of comorbidities in SARS-CoV-2 survivors” (AKTIV SARS-CoV-2): analysis of predictors of short-term adverse outcomes in COVID-19. Russian Journal of Cardiology. 2021;26(4):4470. (In Russ.). doi: https://doi.org/10.15829/1560-4071-2021-4470
8. Zupo R, Castellana F, Sardone R, et al. Preliminary Trajectories in Dietary Behaviors during the COVID-19 Pandemic: A Public Health Call to Action to Face Obesity. Int J Environ Res Public Health. 2020;17(19):7073. doi: https://doi.org/10.3390/ijerph17197073
9. Simonnet A, Chetboun M, Poissy J, et al. LICORN and the Lille COVID-19 and Obesity study group. High Prevalence of Obesity in Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) Requiring Invasive Mechanical Ventilation. Obesity (Silver Spring). 2020;28(7):1195-1199. doi: https://doi.org/10.1002/oby.22831
10. Arutyunov GP, Tarlovskaya EI, Arutyunov AG, et al. Clinical features of post-COVID-19 period. Results of the international register “Dynamic analysis of comorbidities in SARS-CoV-2 survivors (AKTIV SARS-CoV-2)”. Data from 6-month follow-up. Russian Journal of Cardiology. 2021;26(10):4708. (In Russ.). doi: https://doi.org/10.15829/1560-4071-2021-4708.
11. Favre G, Legueult K, Pradier C, et al. Visceral fat is associated to the severity of COVID-19. Metabolism. 2021;115:154440. doi: https://doi.org/10.1016/j.metabol.2020.154440
12. Arutyunov GP, Tarlovskaya EI, Arutyunov AG, et al. International register “Dynamics analysis of comorbidities in SARS-CoV-2 survivors” (AKTIV) and the register “Analysis of hospitalizations of comorbid patients infected during the second wave of SARS-CoV-2 outbreak” (AKTIV 2). Russian Journal of Cardiology. 2021;26(3):4358. (In Russ.). doi: https://doi.org/10.15829/1560-4071-2021-4358
13. Arutyunov GP, Tarnovskaya EI, Arutyunov AG, et al. International registry “Analysis of the dynamics of Comorbid diseases in patients who have been infected with SARSCoV-2 (active SARS-CoV-2)”: methodology and design. Kardiologiia. 2020;60(11):35-37. (In Russ.). doi: https://doi.org/10.18087/cardio.11.n1398
14. Richardson S, Hirsch JS, Narasimhan M, et al. Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area. JAMA. 2020;323(20):2052-2059. doi: https://doi.org/10.1001/jama.2020.6775
15. Casas-Rojo JM, Antón-Santos JM, Millán-Núñez-Cortés J, et al. Características clínicas de los pacientes hospitalizados con COVID-19 en España: resultados del Registro SEMICOVID-19. Rev Clínica Española. 2020;220(8):480-494. doi: https://doi.org/10.1016/j.rce.2020.07.003
16. Drapkina OM, Karpov OE, Loukyanov MM, et al. Experience of creating and the first results of the prospective hospital registry of patients with suspected or confirmed coronavirus infection (COVID-19) and community-acquired pneumonia (TARGET-VIP). Profilakticheskaya Meditsina. 2020;23(8):6-13. (In Russ.). doi: https://doi.org/10.17116/profmed2020230816
17. Raeisi T, Mozaffari H, Sepehri N, et al. The negative impact of obesity on the occurrence and prognosis of the 2019 novel coronavirus (COVID-19) disease: a systematic review and meta-analysis. Eat Weight Disord. 2022;27(3):893-911. doi: https://doi.org/10.1007/s40519-021-01269-3
18. Tarlovskaya EI, Arutyunov AG, Konradi AO, et al. Analysis of influence of background therapy for comorbidities in the period before infection on the risk of the lethal COVID outcome. Data from the international ACTIV SARS-CoV-2 registry («Analysis of chronic non-infectious diseases dynamics after COVID-19 infection in adult patients SARS-CoV-2»). Kardiologiia. 2021;61(9):20-32. (In Russ.). doi: https://doi.org/10.18087/cardio.2021.9.n1680
19. Huang Y, Lu Y, Huang Y-M, et al. Obesity in patients with COVID-19: a systematic review and meta-analysis. Metabolism. 2020;113(8):154378. doi: https://doi.org/10.1016/j.metabol.2020.154378
20. Tamara A, Tahapary DL. Obesity as a predictor for a poor prognosis of COVID-19: A systematic review. Diabetes Metab Syndr. 2020;14(4):655-659. doi: https://doi.org/10.1016/j.dsx.2020.05.020
21. van der Voort PHJ, Moser J, Zandstra DF, et al. Leptin levels in SARS-CoV-2 infection related respiratory failure: A cross-sectional study and a pathophysiological framework on the role of fat tissue. Heliyon. 2020;6(8):e04696. doi: https://doi.org/10.1016/j.heliyon.2020.e04696
22. Longmore DK, Miller JE, Bekkering S, et al. International BMI-COVID consortium. Diabetes and overweight/obesity are independent, nonadditive risk factors for in-hospital severity of COVID-19: An International, Multicenter Retrospective Meta-analysis. Diabetes Care. 2021;44(6):1281-1290. doi: https://doi.org/10.2337/dc20-2676
23. Singh R, Rathore SS, Khan H, et al. Association of obesity with COVID-19 severity and mortality: An updated systemic review, meta-analysis, and meta-regression. Front Endocrinol (Lausanne). 2022;13(8):154378. doi: https://doi.org/10.3389/fendo.2022.780872
24. Lighter J, Phillips M, Hochman S, et al. Obesity in patients younger than 60 years is a risk factor for COVID-19 hospital admission. Clin Infect Dis. 2020;71(15):896-897. doi: https://doi.org/10.1093/cid/ciaa415
25. Yang J, Tian C, Chen Y, et al. Obesity aggravates COVID-19: An updated systematic review and meta-analysis. J Med Virol. 2021;93(5):2662-2674. doi: https://doi.org/10.1002/jmv.26677
26. Soeroto AY, Soetedjo NN, Purwiga A, et al. Effect of increased BMI and obesity on the outcome of COVID-19 adult patients: A systematic review and meta-analysis. Diabetes Metab Syndr. 2020;14(6):1897-1904. doi: https://doi.org/10.1016/j.dsx.2020.09.029
27. Cai Z, Yang Y, Zhang J. Obesity is associated with severe disease and mortality in patients with coronavirus disease 2019 (COVID-19): a meta-analysis. BMC Public Health. 2021;21(1):1505. doi: https://doi.org/10.1186/s12889-021-11546-6
28. Hendren NS, de Lemos JA, Ayers C, et al. Association of body mass index and age with morbidity and mortality in patients hospitalized with COVID-19: results from the American Heart Association COVID-19 cardiovascular disease registry. Circulation. 2021;143(2):135-144. doi: https://doi.org/10.1161/CIRCULATIONAHA.120.051936
29. Watanabe M, Caruso D, Tuccinardi D, et al. Visceral fat shows the strongest association with the need of intensive care in patients with COVID-19. Metabolism. 2020;111(8):154319. doi: https://doi.org/10.1016/j.metabol.2020.154319
30. Monteiro AC, Suri R, Emeruwa IO, et al. Obesity and smoking as risk factors for invasive mechanical ventilation in COVID-19: A retrospective, observational cohort study. PLoS One. 2020;15(12):e0238552. doi: https://doi.org/10.1371/journal.pone.0238552
31. Cariou B, Hadjadj S, Wargny M, et al.; CORONADO investigators. Phenotypic characteristics and prognosis of inpatients with COVID-19 and diabetes: the CORONADO study. Diabetologia. 2020;63(8):1500- 1515. doi: https://doi.org/10.1007/s00125-020-05180-x
32. Batlle D, Soler MJ, Sparks MA, et al.; COVID-19 and ACE2 in Cardiovascular, Lung, and Kidney Working Group. Acute kidney injury in COVID-19: emerging evidence of a distinct pathophysiology. J Am Soc Nephrol. 2020;31(7):1380-1383. doi: https://doi.org/10.1681/ASN.2020040419
33. Ahmadian E, Hosseiniyan Khatibi SM, Razi Soofiyani S, et al. COVID-19 and kidney injury: Pathophysiology and molecular mechanisms. Rev Med Virol. 2021;31(3):e2176. doi: https://doi.org/10.1002/rmv.2176
34. Rhee CM, Ahmadi SF, Kalantar-Zadeh K. The dual roles of obesity in chronic kidney disease: A review of the current literature. Curr Opin Nephrol Hypertens. 2016;25(3):208-216. doi: https://doi.org/10.1097/MNH.0000000000000212
35. Kovesdy CP, Furth SL, Zoccali C, et al. Obesity and kidney disease: hidden consequences of the epidemic. Kidney Int. 2017;91(2):260-262. doi: https://doi.org/10.1016/j.kint.2016.10.019
36. Soto GJ, Frank AJ, Christiani DC, Gong MN. Body mass index and acute kidney injury in the acute respiratory distress syndrome. Crit Care Med. 2012;40(9):2601-2608. doi: https://doi.org/10.1097/CCM.0b013e3182591ed9
37. Ammirati E, Lupi L, Palazzini M, et al. Prevalence, Characteristics, and Outcomes of COVID-19-Associated Acute Myocarditis. Circulation. 2022;145(15):1123-1139. doi: https://doi.org/10.1161/CIRCULATIONAHA.121.056817
38. Castiello T, Georgiopoulos G, Finocchiaro G, et al. COVID-19 and myocarditis: a systematic review and overview of current challenges. Heart Fail Rev. 2022;27(1):251-261. doi: https://doi.org/10.1007/s10741-021-10087-9
39. Haussner W, DeRosa AP, Haussner D, et al. COVID-19 associated myocarditis: A systematic review. Am J Emerg Med. 2022;51(2):150-155. doi: https://doi.org/10.1016/j.ajem.2021.10.001
40. Elkan M, Dvir A, Zaidenstein R, et al. Patient-reported outcome measures after hospitalization during the COVID-19 pandemic: A survey among COVID-19 and non-COVID-19 Patients. Int J Gen Med. 2021;14(2):4829-4836. doi: https://doi.org/10.2147/IJGM.S323316
41. Nittas V, Gao M, West EA, et al. Long COVID through a public health lens: An umbrella review. Public Health Rev. 2022;43(2):4829-4836. doi: https://doi.org/10.3389/phrs.2022.1604501
42. Günster C, Busse R, Spoden M, et al. 6-month mortality and readmissions of hospitalized COVID-19 patients: A nationwide cohort study of 8,679 patients in Germany. PLoS One. 2021;16(8):e0255427. doi: https://doi.org/10.1371/journal.pone.0255427
Supplementary files
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1. Figure 1. BMI index in patients with COVID-19 with different body temperature in the acute infectious period. Note: BMI is body mass index. | |
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Type | Исследовательские инструменты | |
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2. Figure 2. BMI in patients with a new coronavirus infection, depending on the presence of CKD in history. Note: BMI, body mass index; CKD — chronic kidney disease | |
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Type | Исследовательские инструменты | |
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3. Figure 3. The chance of death in patients with NCI depending on BMI in the acute infectious period of SARS-CoV-2. | |
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Type | Исследовательские инструменты | |
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Indexing metadata ▾ |
Review
For citations:
Arutyunov A.G., Tarlovskaya E.I., Galstyan G.R., Batluk T.I., Bashkinov R.A., Arutyunov G.P., Belenkov Yu.N., Konradi A.O., Lopatin Yu.M., Rebrov A.P., Tereshchenko S.N., Chesnikova A.I., Hayrapetyan H.G., Babin A.P., Bakulin I.G., Bakulina N.V., Balykova L.A., Blagonravova A.S., Boldina M.V., Butomo M.I., Vaisberg A.R., Galyavich A.S., Gomonova V.V., Grigoryeva N.Yu., Gubareva I.V., Demko I.V., Evzerikhina A.V., Zharkov A.V., Zateishchikova A.A., Kamilova U.K., Kim Z.F., Kuznetsova T.Yu., Kulikov A.N., Lareva N.V., Makarova E.V., Malchikova S.V., Nedogoda S.V., Petrova M.M., Pochinka I.G., Protasov K.V., Protsenko D.N., Ruzanov D.Yu., Saiganov S.A., Sarybaev A.Sh., Selezneva N.M., Sugraliev A.B., Fomin I.V., Khlynova O.V., Chizhova O.Yu., Shaposhnik I.I., Schukarev D.A., Abdrakhmanova A.K., Avetisyan S.A., Avoyan H.G., Azaryan K.K., Aimakhanova G.T., Ayypova D.A., Akunov A.Ch., Alieva M.K., Almukhambedova A.R., Aparkina A.V., Aruslanova O.R., Ashina E.Yu., Badina O.Yu., Barysheva O.Yu., Batchaeva A.S., Bitieva A.M., Bikhteev I.U., Borodulina N.A., Bragin M.V., Brazhnik V.A., Budu A.M., Bykova G.A., Vagapova K.R., Varlamova D.D., Vezikova N.N., Verbitskaya E.A., Vilkova O.E., Vinnikova E.A., Vustina V.V., Galova E.A., Genkel V.V., Giller D.B., Gorshenina E.I., Grigoryeva E.V., Gubareva E.Yu., Dabylova G.M., Demchenko A.I., Dolgikh O.Yu., Duishobaev M.Y., Evdokimov D.S., Egorova K.E., Ermilova A.N., Zheldybaeva A.E., Zarechnova N.V., Zimina Yu.D., Ivanova S.Yu., Ivanchenko E.Yu., Ilina M.V., Kazakovtseva M.V., Kazymova E.V., Kalinina Yu.S., Kamardina N.A., Karachenova A.M., Karetnikov I.A., Karoli N.A., Karsiev M.Kh., Kaskaeva D.S., Kasymova K.F., Kerimbekova Zh.B., Kim E.S., Kiseleva N.V., Klimenko D.A., Klimova A.V., Kovalishena O.V., Kozlov S.V., Kolmakova E.V., Kolchinskaya T.P., Kolyadich M.I., Kondryakova O.V., Konoval M.P., Konstantinov D.Yu., Konstantinova E.A., Kordyukova V.A., Koroleva E.V., Kraposhina A.Yu., Kryukova T.V., Kuznetsova A.S., Kuzmina T.Yu., Kuzmichev K.V., Kulchoroeva Ch.K., Kuprina T.V., Kuranova I.M., Kurenkova L.V., Kurchugina N.Yu., Kushubakova N.A., Levankova V.I., Ledyaeva A.A., Lisun T.V., Lisyanskaya V.E., Lyubavina N.A., Magdeeva N.A., Mazalov K.V., Mayseenko V.I., Makarova A.S., Maripov A.M., Markov N.V., Marusina A.A., Melnikov E.S., Metlinskaya A.I., Moiseenko N.B., Muradova F.N., Muradyan R.G., Musaelyan Sh.N., Nekaeva E.S., Nikitina N.M., Nifontov S.E., Obolentseva E.Yu., Obukhova A.A., Ogurlieva B.B., Odegova A.A., Omarova Yu.V., Omurzakova N.A., Ospanova Sh.O., Pavlova V.A., Pakhomova E.V., Petrov L.D., Plastinina S.S., Platonov D.A., Pogrebetskaya V.A., Polyakov D.V., Polyakov D.S., Ponomarenko E.V., Popova L.L., Potanin A.A., Prokofieva N.A., Rabik Yu.D., Rakov N.A., Rakhimov A.N., Rozanova N.A., Samus I.V., Serikbolkyzy S., Sidorkina Ya.A., Simonov A.A., Skachkova V.V., Skvortsova R.D., Skuridin D.S., Solovieva D.V., Solovieva I.A., Sukhomlinova I.M., Sushilova A.G., Tagaeva D.R., Titoykina Yu.V., Tikhonova E.P., Tokmin D.S., Tolmacheva A.A., Torgunakova M.S., Trenogina K.V., Trostyanetskaya N.A., Trofimov D.A., Trubnikova M.A., Tulichev A.A., Tursunova A.T., Ulanova N.D., Fatenkov O.V., Fedorishina O.V., Fil T.S., Fomina I.Yu., Fominova I.S., Frolova I.A., Tsvinger S.M., Tsoma V.V., Cholponbaeva M.B., Chudinovskikh T.I., Shavrin I.V., Shevchenko O.A., Shikhaliev D.R., Shishkina E.A., Shishkov K.Yu., Shcherbakov S.Yu., Shcherbakova G.V., Yausheva E.A. The impact of BMI on the course of the acute SARS-COV-2 infection and the risks that emerge during the first year after the hospital discharge. Subanalysis evidence of the AKTIV and AKTIV 2 registries. Problems of Endocrinology. 2022;68(6):89-109. (In Russ.) https://doi.org/10.14341/probl13165

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