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The opportunities to improve therapy adherence in patients with overweight and obesity in real clinical practice

https://doi.org/10.14341/probl13737

Abstract

On September 26, 2025, a meeting of an expert multidisciplinary working group was held in Vladikavkaz, dedicated to discussing ways to improve therapy adherence to modern incretin-based treatments in patients with overweight and obesity in real-world clinical practice.

About the Authors

E. A. Troshina
Endocrinology Research Centre
Russian Federation

Ekaterina A. Troshina - MD, PhD, Professor,

Moscow


L. A. Suplotova
Tyumen State Medical University
Russian Federation

Lyudmila A. Suplotova - MD, PhD, professor,

Tyumen


F. Kh. Dzgoeva
Endocrinology Research Centre
Russian Federation

Fatima Kh. Dzgoeva - MD, PhD,

Moscow


E. V. Ekusheva
Academy of Postgraduate Education of the Federal State Budgetary Institution Federal Scientific and Clinical Center of the Federal Medical and Biological Agency of Russia
Russian Federation

Evgeniya V.Ekusheva - MD, PhD, Professor,

Moscow


E. S. Vyuchnova
Russian University of Medicine
Russian Federation

Elena S. Vyuchnova - MD, PhD,

Moscow


S. V. Okovityi
Saint Petersburg State Chemical Pharmaceutical University; Saint Petersburg State University
Russian Federation

Sergey V. Okovityi - MD, PhD, Professor,

Saint Petersburg


I. G. Bakulin
North-Western State Medical University named after I.I. Mechnikov
Russian Federation

Igor G. Bakulin - MD, PhD, Professor,

Saint Petersburg


N. V. Bakulina
North-Western State Medical University named after I.I. Mechnikov
Russian Federation

Natalia V. Bakulina - MD, PhD, Professor,

Saint Petersburg


T. L. Karonova
V.A. Almazov National Medical Research Center of Endocrinology
Russian Federation

Tatiana L. Karonova - PhD, Chief esearcher, Associate Professor,

Saint Petersburg


G. R. Vagapova
Kazan State Medical University
Russian Federation

Gulnar R. Vagapova - MD, PhD, Professor,

Kazan


T. P. Bardymova
Irkutsk State Medical Academy of Postgraduate Education
Russian Federation

Tatiana P. Bardymova - MD, PhD, Professor,

Irkutsk


M. R. Orazov
Patrice Lumumba Peoples’ Friendship University of Russia
Russian Federation

Mekan R. Orazov - MD, PhD, Professor,

Moscow


O. A. Radaeva
Federal State Budgetary Educational Institution of Higher Education, National Research Ogarev Mordovia State University
Russian Federation

Olga A. Radaeva - Dr. Sci. (Medicine),

Saransk


Z. R. Gusova
Rostov State Medical University
Russian Federation

Zalina R. Gusova - MD, PhD, Assis.Prof.,

Rostov-on-Don


N. A. Matsievskiy
North-Western State Medical University named after I.I. Mechnikov
Russian Federation

Nikolay A. Matsievskiy - MD, PhD,

Saint Petersburg


S. A. Smetanina
Tyumen State Medical University
Russian Federation

Svetlana A. Smetanina - MD, PhD, Associate Professor,

Tyumen


Z. G. Tatarintseva
Kuban State Medical University
Russian Federation

Zoya G. Tatarintseva - MD, PhD,

Krasnodar


Yu. A. Katushkina
Kuban State Medical University
Russian Federation

Yulia A. Katushkina - MD,

Krasnodar


References

1. World Obesity Atlas 2025, https://www.worldobesity.org

2. Nadolsky K, Garvey WT, Agarwal M, Bonnecaze A, Burguera B, et al. American Association of Clinical Endocrinology Consensus Statement: Algorithm for the Evaluation and Treatment of Adults with Obesity/Adiposity-Based Chronic Disease - 2025 Update. Endocr Pract. 2025;31(11):1351-1394. doi: https://doi.org/10.1016/j.eprac.2025.07.017

3. Lincoff AM, Brown-Frandsen K, Colhoun HM, Deanfield J, Emerson SS, et al. Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes. N Engl J Med. 202;389(24):2221-2232. doi: https://doi.org/10.1056/NEJMoa2307563

4. Lincoff AM, Brown-Frandsen K, Colhoun HM, Deanfield J, Emerson SS, et al; SELECT Trial Investigators. Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes. N Engl J Med. 2023;389(24):2221-2232. doi: https://doi.org/10.1056/NEJMoa2307563

5. Packer M, Zile MR, Kramer CM, Baum SJ, Litwin SE, et al; SUMMIT Trial Study Group. Tirzepatide for Heart Failure with Preserved Ejection Fraction and Obesity. N Engl J Med. 2025;392(5):427-437. doi: https://doi.org/10.1056/NEJMoa2410027

6. Kosiborod MN, Abildstrøm SZ, Borlaug BA, Butler J, Rasmussen S, et al; STEP-HFpEF Trial Committees and Investigators. Semaglutide in Patients with Heart Failure with Preserved Ejection Fraction and Obesity. N Engl J Med. 2023;389(12):1069-1084. doi: https://doi.org/10.1056/NEJMoa2306963

7. Loomba R, Hartman ML, Lawitz EJ, Vuppalanchi R, Boursier J, et al; SYNERGY-NASH Investigators. Tirzepatide for Metabolic DysfunctionAssociated Steatohepatitis with Liver Fibrosis. N Engl J Med. 2024;391(4):299-310. doi: https://doi.org/10.1056/NEJMoa2401943

8. Phase 3 ESSENCE Trial: Semaglutide in Metabolic DysfunctionAssociated Steatohepatitis. Gastroenterol Hepatol (N Y). 2024;20(12 Suppl 11):6-7

9. McGowan BM, Bruun JM, Capehorn M, Pedersen SD, Pietiläinen KH, et al; STEP 10 Study Group. Efficacy and safety of once-weekly semaglutide 2·4 mg versus placebo in people with obesity and prediabetes (STEP 10): a randomised, double-blind, placebo-controlled, multicentre phase 3 trial. Lancet Diabetes Endocrinol. 2024;12(9):631-642. doi: https://doi.org/10.1016/S2213-8587(24)00182-7

10. Jastreboff AM, le Roux CW, Stefanski A, Aronne LJ, Halpern B, et al; SURMOUNT-1 Investigators. Tirzepatide for Obesity Treatment and Diabetes Prevention. N Engl J Med. 2025;392(10):958-971. doi: https://doi.org/10.1056/NEJMoa2410819

11. Bliddal H, Bays H, Czernichow S, Uddén Hemmingsson J, Hjelmesæth J, et al; STEP 9 Study Group. Once-Weekly Semaglutide in Persons with Obesity and Knee Osteoarthritis. N Engl J Med. 2024;391(17):1573-1583. doi: https://doi.org/10.1056/NEJMoa2403664

12. Wilding JPH, Batterham RL, Calanna S, Davies M, Van Gaal LF, et al; STEP 1 Study Group. Once-Weekly Semaglutide in Adults with Overweight or Obesity. N Engl J Med. 2021;384(11):989-1002. doi: https://doi.org/10.1056/NEJMoa2032183


Review

For citations:

Troshina E.A., Suplotova L.A., Dzgoeva F.Kh., Ekusheva E.V., Vyuchnova E.S., Okovityi S.V., Bakulin I.G., Bakulina N.V., Karonova T.L., Vagapova G.R., Bardymova T.P., Orazov M.R., Radaeva O.A., Gusova Z.R., Matsievskiy N.A., Smetanina S.A., Tatarintseva Z.G., Katushkina Yu.A. The opportunities to improve therapy adherence in patients with overweight and obesity in real clinical practice. Problems of Endocrinology. 2026;72(1):89-98. (In Russ.) https://doi.org/10.14341/probl13737

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ISSN 0375-9660 (Print)
ISSN 2308-1430 (Online)

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