Preview

User

Not a user? Register with this site Forgot your password?

Problems of Endocrinology

Advanced search

The use of metformin for the treatment of type 2 diabetes mellitus in children and adolescents

https://doi.org/10.14341/probl20135918-13

Abstract

The increasingly higher incidence of type 2 diabetes mellitus (DM2) in the children and adolescent populations implies the necessity of analysis of the effectiveness of currently available therapeutic modalities bearing in mind more aggressive specific complications of the disease in these groups of patients compared with the adult ones. Metformin is the sole oral hypoglycemic agent approved for the use in the children and adolescents with DM2. This paper reports the results of the application of different therapeutic modalities with the use of metformin in the children and adolescents with DM2.

References

1. Swift P.G. Diabetes education. ISPAD Clinical Practice Consensus Guidelines 2006-2007. Pediat Diabet 2007; 8: 102-109.

2. Zimmet P., Alberti K.G., Shaw J. Global and societal implications of the diabetes epidemic. Nature 2001; 414: 782-787.

3. Петеркова В.А., Кураева Т.Л., Ремизов О.В., Щербачева Л.Н. Изучение факторов риска, разработка методов диагностики и лечения сахарного диабета 2-го типа у детей и подростков московской популяции. Методические рекомендации. М 2004; 12.

4. Петеркова В.А., Кураева Т.Л., Ремизов О.В., Щербачева Л.Н., Андрианова Е.А. Сахарный диабет 2-го типа у детей и подростков. Методические рекомендации. М 2005; 14.

5. Arslanian S. Type 2 diabetes in children: clinical aspects and risk factors. Horm Res 2002; 57: Suppl 1: 19-28.

6. Yokoyama H., Okudaira M., Otani T., Sato A., Miura J., Takaike H., Yamada H., Muto K., Uchigata Y., Ohashi Y., Iwamoto Y. Higher incidence of diabetic nephropathy in type 2 than in type 1 diabetes in early-onset diabetes in Japan. J Kidney Int 2000; 58: 302-311.

7. Pavkov M.E., Bennett P.H., Knowler W.C., Krakoff J., Sievers M.L., Nelson R.G. Effect of youth-onset type 2 diabetes mellitus on incidence of end-stage renal disease and mortality in young and middle-aged Pima Indians. JAMA 2006; 296: 4: 421-426.

8. Fagot-Campagna A., Pettitt D.J., Engelgau M.M., Burrows N.R., Geiss L.S., Valdez R., Beckles G.L., Saaddine J., Gregg E.W., Williamson D.F., Narayan K.M. Type 2 diabetes among North American children and adolescents: an epidemiological review and public health perspective. J Pediatr 2000; 136: 664-672.

9. Salpeter S.R., Greyber E., Pasternak G.A., Salpeter E.E. Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus: systematic review and meta-analysis. Arch Intern Med 2003; 24: 163, 2594-2602.

10. Петеркова В.А. Глюкофаж в лечении сахарного диабета 2-го типа у детей и подростков. Фарматека 2008; 17: 171: 61-63.

11. Jones K.L., Arslanian S., Peterkova V.A., Park J.S., Tomlinson M.J. Effect of metformin in pediatric patients with type 2 diabetes: a randomized controlled trial. Diabet Care 2002; 25: 1: 89-94.

12. Laffel L., Chang N., Grey M., Hale D., Higgins L., Hirst K., Izquierdo R., Larkin M., Macha C., Pham T., Wauters A., Weinstock R.S. TODAY Study Group. Metformin monotherapy in youth with recent onset type 2 diabetes: experience from the prerandomization run-in phase of the TODAY study. Pediatr Diabet 2012; 13: 369-375.


Review

For citations:

Eremina I.A., Kuraeva T.L. The use of metformin for the treatment of type 2 diabetes mellitus in children and adolescents. Problems of Endocrinology. 2013;59(1):8-13. https://doi.org/10.14341/probl20135918-13

Views: 666


ISSN 0375-9660 (Print)
ISSN 2308-1430 (Online)

11, Dm. Ul’yanova str., Moscow, Russian Federation, 117292

Processing of personal data
supported by NEICON (Elpub lab)