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Детемир (Левемир): современные парадигмы инсулинотерапии

https://doi.org/10.14341/probl201359456-64

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Аннотация

Особенность структуры молекулы Левемир (детемир), объясняя низкую вариабельность фармакодинамических показателей, определяет более предсказуемый сахароснижающий эффект и меньший риск общих и ночных гипогликемий в различных возрастных группах у пациентов с СД 1-го и 2-го типа, чем при использовании других базальных препаратов инсулина. Помимо этого, инсулин детемир (Левемир) не влияет на массу тела, что объясняется его центральным действием (быстрым проникновением через гематоэнцефалический барьер, регуляцией чувства голода и насыщения, а также улучшением распознавания гипогликемий) и влиянием на синтез гормонов, регулирующих аппетит и энергообмен. Установлены плейотропные эффекты детемира - гепатоселективность, влияние на метаболизм липидов и реабсорбцию натрия.

Об авторах

L Ruiatkina



M Sorokin



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Для цитирования:


., . Детемир (Левемир): современные парадигмы инсулинотерапии. Проблемы Эндокринологии. 2013;59(4):56-64. https://doi.org/10.14341/probl201359456-64

For citation:


Ruiatkina L.A., Sorokin M.I. Detemir (Levemir): modern paradigms of insulin therapy. Problems of Endocrinology. 2013;59(4):56-64. (In Russ.) https://doi.org/10.14341/probl201359456-64

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