Federal clinical recommendations on diagnostics and treatment of hypoparathyroidism in the children and adolescents
https://doi.org/10.14341/probl201460369-74
Abstract
Hypoparathyroidism is a rare etiologically heterogeneous condition that manifests itself in the children in the first place as hypocalcemia. The purely hypocalcemic convulsions are usually interpreted as manifestations of epilepsy which leads to the prescription of an inadequate treatment. The early diagnostics and correct therapy ensure the normal development and social adaptation of the affected child. The present clinical guidelines developed at the Institute of Pediatric Endocrinology, Endocrinological Research Centre, highlight the diagnostic problems pertaining to hypoparathyroidism, as well as its clinical and genetic variants. In addition, the algorithm of diagnostics of hypocalcemic syndrom is proposed in conjunction with the schemes for its treatment.
References
1. Дедов И.И., Петеркова В.А. Справочник детского эндокринолога. – М.: Литтера; 2011. [Dedov II, Peterkova VA. Spravochnik detskogo endokrinologa. Moscow: Littera; 2011.]
2. Davies JH. A Practical Approach to Problems of Hypercalcaemia. Endocrine Development. 2009;16:93-114. doi: 10.1159/000223691
3. Upadhyay J, Steenkamp DW, Milunsky JM. The Syndrome of Hypoparathyroidism, Deafness, and Renal Anomalies. Endocr Pract. 2013;19(6):1035-42. doi: 10.4158/ep13050.ra
4. Lima K, Abrahamsen TG, Wolff AB, Husebye E, Alimohammadi M, Kampe O, et al. Hypoparathyroidism and autoimmunity in the 22q11.2 deletion syndrome. European Journal of Endocrinology. 2011;165(2):345-52. doi: 10.1530/eje-10-1206
5. Mantovani G. Pseudohypoparathyroidism: Diagnosis and Treatment. The Journal of Clinical Endocrinology & Metabolism. 2011;96(10):3020-30. doi: 10.1210/jc.2011-1048
6. Husebye ES. Editorial: Functional Autoantibodies Cause Hypoparathyroidism. The Journal of Clinical Endocrinology & Metabolism. 2009;94(12):4655-7. doi: 10.1210/jc.2009-2123
7. Bassett AS, McDonald-McGinn DM, Devriendt K, Digilio MC, Goldenberg P, Habel A, et al. Practical Guidelines for Managing Patients with 22q11.2 Deletion Syndrome. The Journal of Pediatrics. 2011;159(2):332-9.e1. doi: 10.1016/j.jpeds.2011.02.039
8. Katsanos KH, Elisaf M, Bairaktari E, Tsianos EV. Severe Hypomagnesemia and Hypoparathyroidism in Kearns-Sayre Syndrome. Am J Nephrol. 2001;21(2):150-3. doi: 10.1159/000046239
9. Hannan FM, Thakker RV. Calcium-sensing receptor (CaSR) mutations and disorders of calcium, electrolyte and water metabolism. Best Practice & Research Clinical Endocrinology & Metabolism. 2013;27(3):359-71. doi: 10.1016/j.beem.2013.04.007
10. Díaz-Soto G, Mora-Porta M, Nicolau J, Perea V, Halperin I, Puig-Domingo M. Efficacy and Safety of Long Term Treatment of Unresponsive Hypoparathyroidism Using Multipulse Subcutaneous Infusion of Teriparatide. Horm Metab Res. 2012;44(09):708-10. doi: 10.1055/s-0032-1308971
11. Husebye ES, Perheentupa J, Rautemaa R, Kämpe O. Clinical manifestations and management of patients with autoimmune polyendocrine syndrome type I. J Intern Med. 2009;265(5):514-29. doi: 10.1111/j.1365-2796.2009.02090.x
12. Cusano NE, Rubin MR, Sliney J, Bilezikian JP. Mini-review: new therapeutic options in hypoparathyroidism. Endocrine. 2012;41(3):410-4. doi: 10.1007/s12020-012-9618-y
Review
For citations:
Orlova E.M. Federal clinical recommendations on diagnostics and treatment of hypoparathyroidism in the children and adolescents. Problems of Endocrinology. 2014;60(3):69-74. (In Russ.) https://doi.org/10.14341/probl201460369-74
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