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The state of the testis in the boys presenting with cryptorchism during the mini-pubertal period

https://doi.org/10.14341/probl20146024-7

Abstract

The period of transitory postnatal activation of the hypotalamo-pitutary-gonadal axis (mini-puberty) plays an important role in the testicular maturation and the development of the reproductive system. The objective of the present study was to evaluate the functional condition of the testicles in the boys at the age of 2-3 months born with cryptorchism. A total of 32 boys presenting with inguinal retention of the testes (group 1), 10 patients with unilateral abdominal criptorchism (group 2), and 40 healthy boys ages 2-3 month (control group) were available for the clinical examination and hormonal analysis. The methods employed in the study included orchidometry and genitometry, meagurement of serum gonadotropin, testosterone, and inhibin B levels by immunoenzyme assays. The results investigations made it possible to diagnose gonadal pathology in 80% of the examinad children presenting with unilateral abdominal cryptorchism and subclinical disorders of the testicular function in 40% of the patients with inguinal retention of a testicle.

About the Authors

N Yu Raigorodskaya
Saratov State Medical University named after V.I. Razumovsky, Saratov


N V Bolotova
Saratov State Medical University named after V.I. Razumovsky, Saratov


D A Morozov
Research Centre of Children's Health, Moscow


N B Zakharova
Saratov State Medical University named after V.I. Razumovsky, Saratov


References

1. Bergada´ I, Milani C, Bedecarra´s P, Andreone L, Ropelato MG, Gottlieb S, Bergada´ C, Campo S, Rey RA. Time course of the serum gonadotropin surge, inhibins, and anti-Mu¨llerian hormone in normal newborn males during the first month of life. J Clin Endocrinol Metabol 2006; 91: 4092-4098.

2. Main KM, Toppari J, Skakkebek NE. Gonadal development and reproductive hormones in infant boys. Eur J Endocrinol 2006;155: 51-57.

3. Ji C, Huang XW, Yang RW, Wang XU, Yan Z. Gonadotropins and Sex Hormones in Healthy Chinese Infants. Indian Pediatr 2008;45: 489-492.

4. Svechnikov K, Landreh L, Weisser J. Origin, Development and Regulation of Human Leydig Cells. Horm Res Pediatr 2010; 73: 93-101.

5. Hadziselimovic F, Zivkovic D, Bica DT, Emmons LR. The importance of mini-puberty for fertility in cryptorchidism. J Urol 2005; 174(2): 1536-1539.

6. Hutchison GR, Scott HM, Walker M. Sertoli Cell Development and Function in an Animal Model of Testicular Dysgenesis Syndrome. Biol Reprod 2008; 78: 352-360.

7. Hadziselimovic F, Herzog B. Importance of early postnatal germ cell maturation for fertility of cryptorchid males. Horm Res 2001; 55: 6-10.

8. Hadziselimovic F, Hоecht B, Herzog B, Buser M. Infertility in Cryptorchidism Is Linked to the Stage of Germ Cell Development at Orchidopexy. Horm Res 2007; 68: 46-52.

9. Hadziselimovic F, Hoecht B. Testicular histology related to fertility outcome and postpubertal hormone status in cryptorchidism. Klin Padiatr 2008; 220(5): 302-307.

10. Barthold JS, Manson J, Regan V, Si X, Hassink SG, Coughlin MT, Lee PA. Reproductive hormone levels in infants with cryptorchidism during postnatal activation of the pituitary- testicular axis. J Urol 2004; 172: 1736-1741.

11. Suomi AM, Main KM, Kaleva M, Schmidt IM, Chellakooty M, Virtanen HE, Boisen KA, Damgaard IN, Kai CM, Skakkebеk NE, Toppari J. Hormonal Changes in 3-Month-Old Cryptorchid Boys. Clin Endocrinol Metabol 2006; 91(3): 953-958.

12. Grinspon RP, Rey RA. Anti-Mullerian Hormone and Sertoli Cell Function in Paediatric Male Hypogonadism. Horm Res Pediatr 2010; 73(2): 81-92.

13. Andersson АМ, Toppari J, Haavisto AM, Petersen JH, Simell T, Simell O, Niels E. Longitudinal Reproductive Hormone Profiles in Infants: Pea k of Inhibin B Levels in Infant Boys Exceeds Levels in Adult Men. J Clin Endocrinol Metabol 1999; 83(2): 675-681.

14. Sharpe RM, Fraser HM, Brougham MFH, McKinnell C, Dorris KD, Kelnar CJH,Wallace WH,Walker M. Role of the neonatal period of pituitary-testicular activity in germ cell proliferation and differentiation in the primate testis. Human Reprod 2003; 18: 2110-2117.

15. Boas M, Boisen KA, Virtanen HE, Kaleva M, Suomi AM, Schmidt IM, Damgaard IN, Chellakooty KM, Skakkebek NE, Toppari J, Main KM. Postnatal penile length and growth rate correlate to serum testosterone levels: a longitudinal study of 1962 normal boys. Eur J Endocrinol 2006; 154: 125-129.


Review

For citations:


Raigorodskaya N.Yu., Bolotova N.V., Morozov D.A., Zakharova N.B. The state of the testis in the boys presenting with cryptorchism during the mini-pubertal period. Problems of Endocrinology. 2014;60(2):4-7. (In Russ.) https://doi.org/10.14341/probl20146024-7

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ISSN 0375-9660 (Print)
ISSN 2308-1430 (Online)