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Особенности ожирения и метаболических нарушений при синдроме Прадера-Вилли у детей

https://doi.org/10.14341/probl201460124-31

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Аннотация

Цель исследования - анализ особенностей ожирения и "метаболического фенотипа" у детей с синдромом Прадере-Вилли (СПВ). Приведены результаты клинического и гормонально-метаболического обследования 45 препубертатных детей с генетически подтвержденным диагнозом СПВ (с ожирением и с нормальной массой тела) и контрольной группы из 47 больных с экзогенно-конституциональным ожирением. Несмотря на одинаковую степень ожирения процентное содержание жировой массы у пациентов с СПВ с ожирением было выше, чем у пациентов с экзогенно-конституциональным ожирением (р=0,01), а тощей - ниже (р<0,01). Встречаемость инсулинорезистентности среди детей с СПВ с ожирением составила 11,1%, что ниже, чем среди детей с экзогенно-конституциональным ожирением (42,5%) (p=0,013). Cодержание лептина в крови, встречаемость дислипидемий и процентное содержание жировой массы у детей с СПВ без ожирения были сходны таковыми у детей с экзогенно-конституциональным ожирением.

Об авторах

Н Н Волеводз
ФГБУ «Эндокринологический научный центр» Минздрава России, Москва


Е А Богова
ФГБУ «Эндокринологический научный центр» Минздрава России, Москва


М В Немцова
Медико-генетический научный центр РАМН, Москва


М А Ермакова
Медико-генетический научный центр РАМН, Москва


Т О Чернова
ФГБУ «Эндокринологический научный центр» Минздрава России, Москва


Н И Сазонова
ФГБУ «Эндокринологический научный центр» Минздрава России, Москва


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Для цитирования:


Волеводз Н.Н., Богова Е.А., Немцова М.В., Ермакова М.А., Чернова Т.О., Сазонова Н.И. Особенности ожирения и метаболических нарушений при синдроме Прадера-Вилли у детей. Проблемы Эндокринологии. 2014;60(1):24-31. https://doi.org/10.14341/probl201460124-31

For citation:


Volevodz N.N., Bogova E.A., Nemtsova M.V., Ermakova M.A., Chernova T.O., Sazonova N.I. Peculiar features of obesity and metabolic disorders in the children presenting with Prader-Willi syndrome. Problems of Endocrinology. 2014;60(1):24-31. (In Russ.) https://doi.org/10.14341/probl201460124-31

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