Insulin therapy of type 2 diabetes mellitus in the period of acute stroke: the importance of the insulin administration technique
https://doi.org/10.14341/probl20146054-8
Abstract
Hyperglycemia in the period of acute stroke aggravates prognosis of its outcome in the patients with type 2 diabetes mellitus (DM2). The objective of the present study was to compare the effectiveness and safety of intravenous and subcutaneous ad- ministration of insulin to the patients presenting with DM2 in the period of acute stroke for the achievement of the same target blood glucose level of 7.8-10.0 mmol/l. At admission, the patients were randomized into two groups to be treated either with intravenous (n=36) or subcutaneous (n=37) injections of insulin. Intravenous insulin therapy resulted in a more favourable dynamics of the clinical course of the stroke patients estimated based on the National Institute of Health stroke scale (NIHSS) (p<0.001) and the activity of daily living (ADL) index (p<0.01). Moreover, it was associated with a reduced variability of glyce- mia (p<0.01) and a lower frequency of hypoglycemic episodes (p=0.019) compared with subcutaneous injections.
About the Authors
Leonid G Strongin
Nizhni Novgorod State Medical Academy
Russian Federation
Russian Federation
I G Grigoryan
Nizhni Novgorod State Medical Academy
Russian Federation
Russian Federation
A V Gustov
Nizhni Novgorod State Medical Academy
Russian Federation
Russian Federation
N G Belyaeva
Nizhni Novgorod State Medical Academy
Russian Federation
Russian Federation
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Review
For citations:
Strongin L.G., Grigoryan I.G., Gustov A.V., Belyaeva N.G. Insulin therapy of type 2 diabetes mellitus in the period of acute stroke: the importance of the insulin administration technique. Problems of Endocrinology. 2014;60(5):4-8. (In Russ.) https://doi.org/10.14341/probl20146054-8
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